6 documents found, page 1 of 1
Oxidative Stress, DNA, Cell Cycle/Cell Cycle Associated Proteins and Multidrug ...
Mamede, Ana Catarina Manjolinha; Guerra, S; Laranjo, Marta; Santos, K; Carvalho, Maria J; Carvalheiro, Tiago; Moura, P; Paiva, A; Abrantes, Ana MThe anticancer effects of human amniotic membrane (hAM) have been studied over the last decade. However, the action mechanisms responsible for these effects are not fully understood until now. Previously results reported by our team proved that hAM is able to induce cytotoxicity and cell death in hepatocellular carcinoma (HCC), a worldwide high incident and mortal cancer. Therefore, this experimental study aime...
Selective cytotoxicity and cell death induced by human amniotic membrane in hep...
Mamede, Ana Catarina Manjolinha; Guerra, S; Laranjo, Marta; Carvalho, Maria J; Oliveira, R C; Gonçalves, A C; Alves, R; Castro, L PradoHepatocellular carcinoma (HCC) has a worldwide high incidence and mortality. For this reason, it is essential to invest in new therapies for this type of cancer. Our team already proved that human amniotic membrane (hAM) is able to inhibit the metabolic activity of several human cancer cell lines, including HCC cell lines. Taking into account the previously performed work, this experimental study aimed to inves...
Effect of amniotic membrane proteins in human cancer cell lines: an exploratory...
Mamede, Ana Catarina Manjolinha; Laranjo, Marta; Carvalho, Maria J; Abrantes, Ana M; Pires, A S; Brito, A F; Moura, P; Maia, C J; Botelho, M FHuman amniotic membrane (hAM) has recently drawn attention as an upcoming anti-cancer therapy. Regarding the strategies which have already investigated, little is known about hAM protein extracts (hAMPE) effect on cancer. So, this work aims to study the effect of hAMPE in metabolic activity of several human cancer cell lines. hAMPE were mechanically obtained, thus avoiding the effect of detergents and other rea...
Beyond the limits of oxygen: effects of hypoxia in a hormone-independent prosta...
Mamede, Ana Catarina Manjolinha; Abrantes, Ana M; Pedrosa, L; Lopes, João Casalta; Pires, A S; Teixo, R J; Gonçalves, A C; Ribeiro, A B SarmentoProstate cancer (PCa) has a high incidence worldwide. One of the major causes of PCa resistance is intratumoral hypoxia. In solid tumors, hypoxia is strongly associated with malignant progression and resistance to therapy, which is an indicator of poor prognosis. The antiproliferative effect and induced death caused by doxorubicin, epirubicin, cisplatin, and flutamide in a hormone-independent PCa cell line will...
Amniotic membrane: from structure and functions to clinical applications
Mamede, Ana Catarina Manjolinha; Carvalho, Maria J; Abrantes, Ana M; Laranjo, Marta; Maia, C J; Botelho, M FAmniotic membrane (AM) or amnion is a thin membrane on the inner side of the fetal placenta; it completely surrounds the embryo and delimits the amniotic cavity, which is filled by amniotic liquid. In recent years, the structure and function of the amnion have been investigated, particularly the pluripotent properties of AM cells, which are an attractive source for tissue transplantation. AM has anti-inflammato...
Tomodensitometry and radioisotopic methods in the study of unilateral lung hype...
Baganha, M F; Marques, M A; Botelho, M F; Teixeira, M L; Carvalheira, V; Calisto, J; Silva, A; Fernandes, A; Torres, M; Brito, JAmong the causes of the radiological entity known as unilateral or total hyperlucent lung is the decreased blood flow in the lungs. Unilateral and total hyperlucent lung results, among other factors, from the decreased intrapulmonary blood flow. Classically, the diagnosis and haemodynamic evaluation of these situations were usually made through invasive methods: right heart catheterism to perform angiopneumogra...