11 documents found, page 1 of 2
Physical training prevent and treat hepatic lipid accumulation induced by fruct...
Gaspar, Rafael Calais; Kuga, Gabriel Keine [UNESP]; Muñoz, Vitor Rosetto; Coope, Andressa; Cambri, Lucieli Teresa; Ghezzi, Ana CarolinaMade available in DSpace on 2022-04-28T19:10:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-07-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); This study aims to examine the effects of physical training performed in early (preventive) or late (therapeutic) protocols on body weight gain, glucose tolerance, and triglycerides accumulation in rats fed on a fructose-rich diet. Wistar ra...
Short-term Resistance Training Increases APPL1 Content in the Liver and the Ins...
Minuzzi, Luciele Guerra; Kuga, Gabriel Keine [UNESP]; Breda, Leonardo; Gaspar, Rafael Calais; Muñoz, Vitor Rosetto; Pereira, Rodrigo MartinsMade available in DSpace on 2020-12-12T01:11:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Background APPL1, an adapter protein, interact directly with adiponectin receptors mediating adiponectin signaling and acting as a critical regulator of the crosstalk between adiponectin and insulin signaling pathway. The inadequate level of physical activity, high-calorie intake, or both lead to advers...
Acute physical exercise increases leptin-induced hypothalamic extracellular sig...
Gaspar, Rafael Calais, 1992-; Muñoz, Vitor Rosetto, 1993-; Nakandakari, Susana Castelo Branco Ramos; Minuzzi, Luciele Guerra; Botezelli, José DiegoAgradecimentos: The authors thank Obesity and Comorbidities Research Center – OCRC and FAPESP (2016/18488-8) and CNPq (306535/2017-3) for all support during the experiment; The obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated in the hypotha...
Physical training prevent and treat hepatic lipid accumulation induced by fruct...
Gaspar, Rafael Calais; Kuga, Gabriel Keine; Muñoz, Vitor Rosetto; Coope, Andressa; Cambri, Lucieli Teresa; Ghezzi, Ana CarolinaThis study aims to examine the effects of physical training performed in early (preventive) or late (therapeutic) protocols on body weight gain, glucose tolerance, and triglycerides accumulation in rats fed on a fructose-rich diet. Wistar rats were allocated into two major groups according to the diet received: Control (C- standard diet) and Fructose (F- diet containing 60% fructose) fed during 120 days. ...
Hippocampal insulin signaling and neuroprotection mediated by physical exercise...
Kuga, Gabriel Keine; Botezelli, José Diego; Gaspar, Rafael Calais; Gomes, Ricardo José; Pauli, José Rodrigo; Leme, José Alexandre Curiacos De AlmeidaMade available in DSpace on 2018-11-12T17:27:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2017. Added 1 bitstream(s) on 2018-11-12T17:35:33Z : No. of bitstreams: 1 S1980-65742017000500201.pdf: 357050 bytes, checksum: b0ba95ed51c3a816b481b58262058c86 (MD5); Abstract Epidemiological studies indicate continuous increases in the prevalence of Alzheimer’s Disease (AD) in the next few decades. The key f...
Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduce...
Rodrigues, Bárbara de Almeida; Kuga, Gabriel Keine [UNESP]; Muñoz, Vitor Rosetto; Gaspar, Rafael Calais; Tavares, Mariana Rosolen; Botezelli, José DiegoMade available in DSpace on 2018-12-11T16:49:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-17; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The mitogen-activated kinase phosphatase-3 (MKP-3) has gained great importance in the scientific community by acting as a regulator of the cell cycle through dephosphorylation of FoxO1, an important transcription factor involved in the insul...
Impaired insulin signaling and spatial learning in middle-aged rats: The role o...
Kuga, Gabriel Keine [UNESP]; Muñoz, Vitor Rosetto; Gaspar, Rafael Calais; Nakandakari, Susana Castelo Branco Ramos; da Silva, Adelino Sanchez RamosMade available in DSpace on 2018-12-11T16:51:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-04-01; The insulin and Brain-Derived Neurotrophic Factor (BDNF) signaling in the hippocampus promotes synaptic plasticity and memory formation. On the other hand, aging is related to the cognitive decline and is the main risk factor for Alzheimer's Disease (AD). The Protein-Tyrosine Phosphatase 1B (PTP1B) is r...
Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus...
Gaspar, Rafael Calais; Muñoz, Vitor Rosetto; Formigari, Guilherme Pedron; Kuga, Gabriel Keine [UNESP]; Nakandakari, Susana Castelo Branco RamosMade available in DSpace on 2018-12-11T16:53:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-10-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Adiponectin is considered an adipokine that has essential anti-inflammatory and insulin-sensitivity actions. The adaptor protein containing the pleckstrin homology domain,...
Capacidade aeróbia de ratos da linhagem wistar: efeito do treinamento físico e ...
Ghezzi, Ana Carolina; Cambri, Lucieli Teresa; Araújo, Gustavo Gomes de; Botezelli, José Diego; Ribeiro, Carla; Mello, Maria Alice Rostom deIt has been shown that engaging in regular physical exercise yields short- and long-term health benefits, primarily by mitigating the risk for cardiovascular disease, but little information is known about physical deconditioning at aging process. The aim of the present study was to analyze the aerobic capacity, through maximal lactate steady state (MLSS), in Wistar rats of different ages (2,4, 6 e 12 months ) a...
Transcriptional and molecular pathways activated in mesenteric adipose tissue a...
Coope, Andressa; Biazzo, Lívia Aparecida Davila Bitencourt Pascoal; Silva, Francesca Aparecida Ramos da, 1982-; Botezelli, José DiegoAbstract: Crohn’s disease (CD) is a chronic inflammatory disorder, characterized by cytokine imbalance and transcription signaling pathways activation. In addition, the increase of mesenteric adipose tissue (MAT) near the affected intestinal area is a hallmark of CD. Therefore, we evaluated the transcription signaling pathways and cytokines expression in intestinal mucosa and MAT of active CD patients. Ten pati...