3 documents found, page 1 of 1
Prolonged intracellular accumulation of light-inducible nanoparticles in leukem...
Boto, Carlos; Quartin, Emanuel; Cai, Yijun; Martín-Lorenzo, Alberto; Cenador, María Begoña García; Pinto, Sandra; Gupta, Rajeev; Enver, TariqLeukaemia cells that are resistant to conventional therapies are thought to reside in protective niches. Here, we describe light-inducible polymeric retinoic acid (RA)-containing nanoparticles (NPs) with the capacity to accumulate in the cytoplasm of leukaemia cells for several days and release their RA payloads within a few minutes upon exposure to blue/UV light. Compared to NPs that are not activated by light...
Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive ...
Santos, Tiago; Ferreira, Raquel; Quartin, Emanuel; Boto, Carlos; Saraiva, Cláudia; Bragança, José; Peça, João; Rodrigues, Cecília; Ferreira, LinoPreprint version; The authors would like to thank Ana Clara Cristóvão for her contributions. This work was funded by Fundação para a Ciência e Tecnologia (FCT), FEDER and COMPETE; (PTDC/SAU-NEU/104415/2008, FCOMP-01-0124-FEDER-041099, SFRH/BD/79526/2011), L'Oréal-UNESCO Portugal for Women in Science, Professor Francisco Pulido Valente Foundation, EC (ERC project no. 307384, “Nanotrigger”), COMPETE (Centro-07-ST...
Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive ...
Santos, Tiago; Ferreira, Raquel; Quartin, Emanuel; Boto, Carlos; Saraiva, Claudia; Bragança, José; Peca, Joao; Rodrigues, Cecilia; Ferreira, LinoNeurogenic niches constitute a powerful endogenous source of new neurons that can be used for brain repair strategies. Neuronal differentiation of these cells can be regulated by molecules such as retinoic acid (RA) or by mild levels of reactive oxygen species (ROS) that are also known to upregulate RA receptor alpha (RAR alpha) levels. Data showed that neural stem cells from the subventricular zone (SVZ) expos...