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Adrenal Vein Sampling in the Management of Primary Aldosteronism: The Added Val...

Manique, I; Amaral, S; Matias, A; Bouça, B; Serranito, S; Torres, J; Gutu, O; Bilhim, T; Coimbra, E; Rodrigues, I; Godinho, C; Cortez, L; Silva-Nunes, J

Introduction: Primary aldosteronism is the most common cause of secondary hypertension. Adrenal vein sampling is the gold standard for subtyping primary aldosteronism. However, this procedure is technically challenging and often has a low success rate. Our center is one of the very few performing this technique in our country with an increasing experience. Objective: The aim of this study was to evaluate the ro...


Central Diabetes Insipidus Following Immunization With BNT162b2 mRNA COVID-19 V...

Bouça, B; Roldão, M; Bogalho, P; Cerqueira, L; Silva-Nunes, J

Introduction: Cases of central diabetes insipidus (CDI) have been reported after COVID-19 infection, with hypophysitis being the most likely cause. COVID-19 vaccines potential adverse effects may mimetize some of these complications. Case report: Woman 37 years old, with rheumatoid arthritis under adalimumab (40 mg twice a month) since December 2018. She was in her usual state of health when she has received th...


The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragang...

Bouça, B; Bogalho, P; Rizzo, M; Silva-Nunes, J

Pheochromocytoma and paragangliomas (PPGL) are rare neuroendocrine tumors. In some patients they exhibit malignant behavior characterized by the presence of metastases, limiting treatment options and survival rates. Therapeutic options are limited to surgery, localized radiotherapy, and a few systemic therapies. However, in several recent studies, non-coding RNA molecules are gaining increasing attention as mar...


Nefropatia Diabética

Bouça, B; Bogalho, AP; Agapito, A

A Nefropatia Diabética (ND) é a principal causa de doença renal crónica estádio 5. O aumento da albuminúria é considerado o pilar da fisiopatologia da ND, mas não é um biomarcador específico ou preditor da história natural da doença. A otimização do controlo glicémico é fundamental na prevenção do aparecimento e da progressão da nefropatia. No entanto, muitos outros fatores demonstraram interferir na evolução d...


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