56 documents found, page 1 of 6
Integration of omics to explore novel disease pathways in Down syndrome neurode...
Barros-Santos, Beatriz; Campos-Marques, Carlos; Salvador, Andreia Filipa Ferreira; Silva, Joana Margarida Gonçalves MotaDown Syndrome is characterized by the trisomy of chromosome 21, leading to widespread molecular and neurological alterations, including early-onset Alzheimer's disease. Emerging evidence highlights the role of RNA metabolism, RNA-binding proteins, and stress granules in these processes. The integrated stress response, a key regulator of translation and protein homeostasis, may be particularly disrupted in DS du...
Strategies to increase prebiotic activity and neurotrophic potential through di...
Silva, Soraia P.; Gonzalez, Abigail; Roupar, Dalila; Salvador, Andreia Filipa Ferreira; Bastos, Rita; Mota, Mariana; Luís, Maria H.; Ferreira, Sónia S.Soluble polysaccharides and oligosaccharides are prebiotic compounds that promote the growth of beneficial gut bacteria and contribute to improved health. Industrial juice production results in juices with moderate amounts of soluble dietary fibre because most polysaccharides that constitute the dietary fibre are retained in the pulp. Incorporation of glucanases and pectinases into the juice production process ...
Structural characterization and in vitro gut microbiota fermentation of a polys...
Silva, Francisca Crislândia Oliveira; Araújo, Maria Isabela Ferreira de; Silva, Soraia P.; Coelho, Elisabete; Santos, Aline Teixeira dosAvailable online 14 May 2025; This study aims to structurally characterize a polysaccharide extracted from Cenostigma nordestinum gum (AGCn) and evaluate its prebiotic potential in human gut microbiota. AGCn, obtained by dissolution in water and precipitation in 70 % ethanol, was primarily composed of carbohydrates (93.61 %), with a low protein content (1.70 %) and some phenolic compounds (9.16 % Gallic Acid Eq...
Microbial activity of the inoculum determines the impact of activated carbon, m...
Braga, Cátia Sofia Neves; Martins, Gilberto; Duarte, Maria Salomé Lira; Soares, O. Salomé G. P.; Pereira, M. Fernando R.; Pereira, Inês A. C.Available online 7 January 2025; The conversion of organic matter to methane through anaerobic digestion (AD) process can be enhanced by different materials. However, literature reports show inconsistent results on the effect of materials in different AD systems. In this study, we evaluated the influence of the inoculum's activity on methane production (MP) efficiency in the presence of different materials (act...
Estimating the biodegradation of PHB/PBAT films - An experimental design approach
Fernandes, Miguel ângelo Cavaleiro; Salvador, Andreia Filipa Ferreira; Madalena, Daniel Alexandre Silva; Vicente, A. A.Available online 8 January 2025; The massive use of plastics in various applications, particularly packaging, generates enormous amounts of plastic waste that can be found almost everywhere, including in soil. This represents a serious environmental pollution issue since the biodegradability in soils can take several years, depending on the microbial composition, the physical and chemical characteristics of pla...
Individual-based modelling elucidates about the role of nanomaterials on methan...
Sequeira, João C.; Li, Bowen; Alves, M. M.; Rocha, Miguel; Curtis, Tom P.; Salvador, Andreia Filipa FerreiraModelling stands as a potent tool for the simulation of real-world systems, offering predictive insights into their dynamic behaviours. Individual-Based Models (IBMs), with their ability to capture intricate details at the microscale, emerge as particularly valuable tools. In the context of anaerobic digestion (AD), the application of IBMs gains significance. Some nanomaterials (NM) enhance methane production i...
Deciphering the impact of activated carbon, magnetite and zeolite on the activi...
Braga, Cátia Sofia Neves; Martins, Gilberto; Duarte, Maria Salomé Lira; Costa, João Carlos Sequeira; Soares, O. S. G. P.; Pereira, M. F. R.Biomethane has a paramount role in the emergent energy transition occurring in Europe, and biotechnological strategies to accelerate biomethane production are needed. In this work, we investigated the effect of several materials (activated carbon (AC), magnetite and zeolite) on the activity of methanogenic cultures, including pure cultures and complex microbial communities. Anaerobic incubations were set up wit...
Tratamento de águas residuais sintéticas contaminadas com carbamazepina usando ...
Costa, Mariana; Mesquita, D. P.; Salvador, Andreia Filipa Ferreira; Silva, Ana R.; Ferreira, Eugénio C.; Quintelas, Cristina Maria CatalãoUm reator descontínuo sequencial (SBR) inoculado com lamas granulares (AGS) foi utlizado para tratar água residual sintética contaminada com carbamazepina (CBZ) a três concentrações distintas: 2, 5 e 8 mg/L. As maiores taxas de remoção foram observadas a 8 mg/L, tendo-se, no entanto, observado grandes oscilações na eficiência de remoção ao longo dos três ensaios. Estas oscilações devem-se, muito provavelmente, ...
Desafios e soluções na gestão de águas residuais têxteis: Uma abordagem biológica
Barbosa, Sónia G.; Nicolau, Ana; Silva, Ana R.; Salvador, Andreia Filipa Ferreira; Soares, Olívia S. G. P.; Pereira, Manuel Fernando R.; Gonçalves, AnaOs processos da indústria têxtil consomem grandes volumes de água e geram efluentes resistentes aos processos de tratamento convencionais. Uma gestão eficaz da água requer tecnologias de tratamento que enfrentem a complexidade e variabilidade dos efluentes, assegurando qualidade para reutilização em processos húmidos. Neste estudo testaram-se tratamentos biológicos anaeróbios e aeróbios, suplementados com 2 tip...
Microplastics biodegradation by estuarine and landfill microbiomes
Pires, Cristina S.; Costa, Luís; Barbosa, Sónia G.; Sequeira, João Carlos; Cachetas, Diogo Macedo; Freitas, José; Martins, Gilberto; Machado, Ana VeraPlastic pollution poses a worldwide environmental challenge, affecting wildlife and human health. Assessing the biodegradation capabilities of natural microbiomes in environments contaminated with microplastics is crucial for mitigating the effects of plastic pollution. In this work, we evaluated the potential of landfill leachate (LL) and estuarine sediments (ES) to biodegrade polyethylene (PE), polyethylene t...