31 documents found, page 1 of 4
Editorial Acknowledgment to Reviewers of Scientific Letters in 2024
Bousbaa, HassanOn behalf of the Editorial Team of Scientific Letters, I would like to express our gratitude to the dedicated reviewers who have contributed to the success of the journal throughout 2024. Their unwavering commitment to ensuring the high quality of the articles published in Scientific Letters has been invaluable. This year, as in previous ones, we have been impressed by the consistent quality of the reviews, whi...
Exploring Innovations and Key Insights in Healthcare
Cortes, Arthur R. G.; Henriques, Bruno; Sarmento, Bruno; Rodrigues, Célia Fortuna; Souza, Júlio C. M.; Tiritan, Maria Elizabeth; Brito, Nuno VieiraOn behalf of the Editorial Team of Scientific Letters, we are pleased to announce the publication of the third issue. The 2024 edition of Scientific Letters presents a diverse array of research that highlights significant advancements in health, dentistry, and clinical treatments.
Evaluation of antitumor activity of xanthones conjugated with amino acids
Barbosa, Flávia; Araújo, Joana; F. Gonçalves , Virgínia M.; Palmeira, Andreia; Cunha, Andrea; A. Silva, Patrícia M.; Fernandes, Carla; Pinto, MadalenaBackground: Cancer is a complex disease characterized by several alterations that confer on the cells, the capacity to proliferate uncontrollably and to resist cellular death. Multiresistance to conventional chemotherapy drugs is often the cause of treatment failure; thus, the search for natural products or their derivatives with therapeutic action is essential. Chiral derivatives of xanthones (CDXs) have ...
KSP and MPS1 kinases as potential therapeutic targets for ovarian cancer
Sampaio, Francisca; Gomes, Carina; Silva, João P. N.; Bousbaa, Hassan; Silva, Patrícia M. A.Background: Ovarian cancer ranks among the top causes of cancer-related deaths in women worldwide [1]. The conventional treatment for ovarian cancer involves surgery and chemotherapy, typically using a combination of paclitaxel and carboplatin [2]. However, despite the initial positive response to this treatment regimen, the development of treatment resistance has emerged as a significant challenge in managing ...
KSP and Aurora B as potential biomarkers and therapeutic targets for head and n...
Silva, João P. N.; Silva, Raquel; Vilas-Boas, Maria Do Carmo; Silva, Patrícia M. A. Silva; Bousbaa, HassanBackground: Head and neck cancer (HNC) is the seventh most prevalent worldwide [1]. The treatment for HNC often involves a combination of modalities such as surgery, radiation therapy, and chemotherapy. However, HNC patients’ survival rate has shown little improvement [2]. Treatment failures are often attributed to local recurrence, lymph node metastases, and drug resistance [3]. Hence, the need for new biomark...
Developing robust heterotypic 3D lung cancer cultures for drug screening: preli...
Pinto, Bárbara; A. Silva, Patrícia M.; Sarmento, Bruno; Carvalho-Tavares, Juliana; Bousbaa, HassanBackground: To propel advancements in cancer treatment, it is imperative to conduct initial drug testing using in vitro models. In laboratory settings, the efficacy of most compounds is rigorously evaluated through 2D cell cultures. However, many compounds showing promise in these models fail to perform similarly in preclinical or clinical trials, prolonging the timeline for developing effective drugs for human...
Editorial Acknowledgment to Reviewers of Scientific Letters in 2023
Bousbaa, HassanOur commitment to prioritizing quality over quantity in the papers published in Scientific Letters remains steadfast. The overall quality of the journal is greatly indebted to the dedicated work of the Reviewers listed below. These Reviewers are chosen based on their expertise and, throughout 2023, we have been impressed by the consistently high quality of their evaluations. Reviewers selflessly invest their ti...
The Brightness of Multidisciplinary Approaches in Health Sciences Research
Cortes, Arthur R. G.; Henriques, Bruno; Sarmento, Bruno; Rodrigues, Célia Fortuna; Souza, Júlio C. M.; Tiritan, Maria Elizabeth; Brito, Nuno VieiraOn behalf of the Editorial Team of Scientific Letters journal, we are pleased to announce the publication of the second issue. The second issue comprises four scientific papers, encompassing two reviews and two research articles. In 2023, Scientific Letters also published two special issues in the form of Books of Abstracts. These publications compile all abstracts that were accepted for presentation at the II ...
Exploring the Clinical Relevance of p31comet in Head and Neck Squamous Cell Car...
Henriques, Ana C. Henriques; Silva , João P. N.; Pinto, Bárbara; Silva, Patricia M. A.; Bousbaa, HassanThe p31comet protein plays a pivotal role in regulating spindle assembly checkpoint silencing and is overexpressed in several cancers, including oral cancer. Despite this, its exact roles in tumorigenesis and its prognostic significance remain unclear. In this study, using the UALCAN cancer database, we analyzed p31comet expression and its correlation with clinical indicators in Head and Neck Squamous Cell Carc...
Co-inhibition of MPS-1 with BCL-2 family inhibitors enhances lung cancer cell k...
Pinto, B.; Silva, P.; Sarmento, B.; Carvalho-Tavares, J.; Bousbaa, HassanBackground: Lung cancer is the leading cause of cancer death worldwide, posing a significant public health challenge [1]. Currently available therapies, when administered as monotherapy, have limited efficacy, high toxicity, and can lead to increased tumor resistance. Overexpression of MPS-1, a protein kinase involved in mitosis, has been observed in various types of tumors. Its inhibition is associated with ab...