3 documents found, page 1 of 1
Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomi...
Barbosa, Alexandre Naime [UNESP]; Ferreira, Rui Seabra [UNESP]; de Carvalho, Francilene Capel Tavares [UNESP]; Schuelter-Trevisol, FabianaMade available in DSpace on 2021-06-25T10:57:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-23; We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee (Apis mellifera) Antivenom (AAV) in a phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20 participants with multiple stings. Participants received 2 to 10 vials of AAV ...
Long-term safety and efficacy of patisiran for hereditary transthyretin-mediate...
Adams, David; Polydefkis, Michael; González-Duarte, Alejandra; Wixner, Jonas; Kristen, Arnt V.; Schmidt, Hartmut H.; Berk, John L.Background: Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Methods: This multicentre, open-label ex...
A clinical trial protocol to treat massive Africanized honeybee (Apis mellifera...
Barbosa, Alexandre Naime [UNESP]; Boyer, Leslie; Chippaux, Jean-Philippe; Medolago, Natalia Bronzatto [UNESP]; Caramori, Carlos Antonio [UNESP]Made available in DSpace on 2018-12-11T17:10:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-16. Added 1 bitstream(s) on 2021-07-15T15:21:48Z : No. of bitstreams: 1 S1678-91992017000100309.pdf: 628343 bytes, checksum: 154f2f153e36ae6b7b781823c75a2ab4 (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Background: Envenomation caused by multiple stings from Africanized honeybees Ap...