8 documents found, page 1 of 1
Surface modification of an intraocular lens material by plasma-assisted graftin...
Vieira, A. Paula; Pimenta, Andreia F. R.; Silva, Diana; Gil, M. Helena; Alves, Patrícia; Coimbra, Patrícia; Mata, José L. G. C.; Bozukova, DimitriyaEndophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed as an alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used...
Controlled release of moxifloxacin from intraocular lenses modified by Ar plasm...
Pimenta, Andreia; Vieira, Ana Paula; Colaco, Rogério; Saramago, Benilde; Gil, Maria; Coimbra, Patrícia; Alves, Patrícia; Bozukova, DimitriyaIntraocular lenses (IOLs) present an alternative for extended, local drug delivery in the prevention of post-operative acute endophthalmitis. In the present work, we modified the surface of a hydrophilic acrylic material, used for manufacturing of IOLs, through plasma-assisted grafting copolymerization of 2-acrylamido-2-methylpropane sulfonic acid (AMPS) or [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammo...
Surface modification of an intraocular lens material by plasma-assisted graftin...
Vieira, Ana Paula; Pimenta, Andreia; Silva, Diana; Gil, Maria; Alves, Patrícia; Coimbra, Patrícia; Mata, Jose; Bozukova, Dimitriya; Correia, Tiago R.Endophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed as an alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used...
Effect of sterilization on drugs and lenses for ophthalmic applications
Topete, Ana; Oliveira, Andreia; Galante, Raquel; Bozukova, Dimitriya; Saramago, Benilde; Serro, A. P.
Sterilization of intraocular lenses loaded with moxifloxacin
Filipe, Helena P.; Oliveira, Andreia; Moutinho, M. Guilhermina; Bozukova, Dimitriya; Saramago, Benilde; Serro, A. P.
Chitosan/alginate based multilayers to control drug release fromophthalmic lens
Silva, Diana; Pinto, Luís F. V.; Bozukova, Dimitriya; Santos, Luís F.; Serro, Ana Paula; Saramago, BenildeIn this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Defi...
Diclofenac release from a silicon based contact lens material controlled by a c...
Filipe, Helena; Silva, Diana; Pinto, Luís F. V.; Henriques, José; Bozukova, Dimitriya; Saramago, Benilde; Serro, Ana Paula
Sterilization of ophthalmic drugs and intraocular lenses
Oliveira, Andreia; Moutinho, Guilhermina M.; Bozukova, Dimitriya; Saramago, Benilde; Serro, A. P.