11 documents found, page 1 of 2
The Festivity in Honour of Our Lady of Antime in Fafe: An emerging tourist reso...
Braga, José Luís; Mota, Catarina; Brás, Sandra; Borges, IsabelThe aim of this study was to analyse the motivations of the participants of the festivity in honour of Our Lady of Antime in Fafe (located in the north of Portugal) and provide an overview of the tourism opportunities and impacts associated with the event. To this end, the study analysed the main events on the programme for the 2024 edition of this religious festivity. According to the interviews and participan...
Using routes or itineraries to create networks in regions with low competitiveness
Martins, Oliva M.D.; Figueira, Luís Mota; Braga, José Luís; Borges, Isabel; Magalhães, Miguel; Brás, SandraThere are territories where the ability of territorial competitiveness can be conditioned by the availability of resources, access, and capacity to attract and retain tourists. The barrier of competitiveness of territories, especially desertified territories with scarce resources, can be overcome through the involvement of all and the integration of stakeholders in a collaborative network. In this sense, with t...
Identifying new opportunities from the pandemic crisis
Coelho, Ana Sofia; Costa, José Paulo; Brás, Sandra; Martins, Oliva M.D.The pandemic crisis has changed economic and social behaviors. Companies are trying to redesign their products in order to identify new segments of the market. So, the research raises the present question: is it possible to react to market dynamics with the same speed, intensity, and frequency as they occur? Aiming to understand this process, the objective of this investigation is to explore best practices deve...
Immunogenetic protective factors in Genetic Generalized Epilepsy
Chaves, João; Martins-Ferreira, Ricardo; Ferreira, Ana Marta; Brás, Sandra; Carvalho, Cláudia; Bettencourt, Andreia; Samões, Raquel; Monteiro, FábioBackground: Genetic Generalized Epilepsies (GGEs) are a heterogeneous group of syndromes characterized by generalized seizure activity that affects both hemispheres, with mainly genetic causes. Neuroinflammation has been established as an important mechanism in epileptogenesis. The ability to develop an appropriated immune response is strongly determined by immunogenetic factors. In this setting, our aim was to...
Apolipoprotein E isoforms and susceptibility to genetic generalized epilepsies
Chaves, João; Martins-Ferreira, Ricardo; Carvalho, Cláudia; Bettencourt, Andreia; Brás, Sandra; Chorão, Rui; Freitas, Joel; Samões, Raquel; Lopes, JoãoBackground: Apolipoprotein E (ApoE) is the main lipoprotein secreted in brain. It has a critical immunomodulatory function, influences neurotransmission and it is involved in repairing damaged neurons. ApoE e4 is an isoform of ApoE with altered function, and was previously associated with early onset epilepsy and refractoriness, both in animal models and in patients with focal epilepsies. There is a limited kno...
Immunogenetic predisposing factors for mesial temporal lobe epilepsy with hippo...
Leal, Bárbara; Chaves, João; Carvalho, Cláudia; Bettencourt, Andreia; Brito, Cláudia; Boleixa, Daniela; Freitas, Joel; Brás, Sandra; Lopes, JoãoPurpose: Neuroinflammation appears as an important epileptogenic mechanism. Experimental and clinical studies have demonstrated an upregulation of pro-inflammatory cytokines such as IL-1β and TNF-α, in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Expression of these cytokines can be modulated by polymorphisms such as rs16944 and rs1800629, respectively, both of which have been associated ...
Práticas de e-learning e a sua relação com o mercado de trabalho: o caso da RIP...
Brás, Sandra; Teixeira, AntónioCom o aumento do número de cursos online e a necessidade de conhecimentos específicos para as tarefas e responsabilidades diárias dos trabalhadores, tornou-se indispensável adaptar os cursos desenvolvidos pelas organizações às necessidades dos trabalhadores, das empresas e do mercado de trabalho. Seguindo uma lógica de work-based learning, a RIPE NCC (Réseaux Internet Protocol Européens Network Coordina tion Ce...
HLA and age of onset in myasthenia gravis
Santos, Ernestina; Bettencourt, Andreia; da Silva, Ana Martins; Boleixa, Daniela; Lopes, Dina; Brás, Sandra; Costa, Paulo Pinho E.; Lopes, CarlosThe aetiology of MG is unknown, but both genetic and environmental factors are important. Over the years association of MG with Human Leucocyte Antigens (HLA) has been described in different populations. We investigated a possible association between HLA-DRB1 alleles and age of onset in MG. One hundred and fourteen MG patients (82 females) and 282 control individuals (CP) were studied. Patients were classified ...
The vitamin D receptor gene FokI polymorphism and Multiple Sclerosis in a North...
Bettencourt, Andreia; Boleixa, Daniela; Guimarães, Ana Luísa; Leal, Bárbara; Carvalho, Cláudia; Brás, Sandra; Samões, Raquel; Santos, ErnestinaThe cause of Multiple Sclerosis (MS) remains poorly understood, but it is widely believed to be an autoimmune disease occurring in genetically susceptible individuals after exposure to as-yet undefined environmental factors. One of these environmental factors is vitamin D, a well-known immune modulator. The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3, has been shown to exert its immune modul...
The Protective Role of HLA-DRB1(*)13 in Autoimmune Diseases
Bettencourt, Andreia; Carvalho, Cláudia; Leal, Bárbara; Brás, Sandra; Lopes, Dina; Martins da Silva, Ana; Santos, Ernestina; Torres, TiagoAutoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background, with the MHC region playing a major role. We genotyped for HLA-DRB1 locus 1228 patients with AIDs-213 with Systemic Lupus Erythematosus (SLE), 166 with Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 with Rheumatoid Arthritis (RA), 67 with Systemic Sclerosis (SSc), 536 with Multiple Sclerosis (MS), and ...