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Characterisation of physiological responses to odours in autism spectrum disord...

Pereira, Lara; Grave, Joana; Noll, Janina; Derntl, Birgit; Soares, Sandra C.; Brás, Susana; Sebastião, Raquel

Abnormal sensory perception is among the earliest symptoms of autism spectrum disorders (ASD). Despite mixed findings, olfactory perception seems to be altered in ASD. There is also evidence that automatic responses to odours can serve as biomarkers of ASD. However, this potential use of odour-based biomarkers for ASD is still underexplored. In this study, we aimed to investigate whether physiological responses...


Transcriptome mining to identify molecular markers for the diagnosis of Staphyl...

Brás, Susana; França, Ângela Maria Oliveira Sousa

Bloodstream infections caused by Staphylococcus epidermidis are often misdiagnosed since no diagnostic marker found so far can unequivocally discriminate true infection from sample contamination. While attempts have been made to find genomic and/or phenotypic differences between invasive and commensal isolates, possible changes in the transcriptome of these isolates under in vivo-mimicking conditions have not b...


Analysis of physiological responses during pain induction

Sebastião, Raquel; Bento, Ana; Brás, Susana

Pain is a complex phenomenon that arises from the interaction of multiple neuroanatomic and neurochemical systems with several cognitive and affective processes. Nowadays, the assessment of pain intensity still relies on the use of self-reports. However, recent research has shown a connection between the perception of pain and exacerbated stress response in the Autonomic Nervous System. As a result, there has b...


A Preliminary study on electrocardiogram response during pain induction

Bento, Ana; Brás, Susana; Sebastião, Raquel

Pain is a complex phenomenon that arises from the interaction of multiple neuroanatomic and neurochemical systems with several cognitive and affective processes. Nowadays, the assessment of pain intensity still relies on the use of self-reports. However, recent research has shown a connection between the perception of pain and exacerbated stress response on the Autonomic Nervous System (ANS). The ANS, which is ...


Characterization of emotions through facial electromyogram signals

Pereira, Lara; Brás, Susana; Sebastião, Raquel

Emotions are a high interesting subject for the development of areas such as health and education. As a result, methods that allow their understanding, characterization, and classification have been under the attention in recent years. The main objective of this work is to investigate the feasibility of characterizing emotions from facial electromyogram (EMG) signals. For that, we rely on the EMG signals, from ...


Exploring alterations in electrocardiogram during the postoperative pain

Pais, Daniela; Brás, Susana; Sebastião, Raquel

The assessment of postoperative pain after a surgical procedure is a critical step to guarantee a suitable analgesic control of pain, and currently, it is based on the self-reports of the patients. However, these assessment methods are subjective, discontinuous, and inadequate for evaluating the pain of patients unable or with limited ability to communicate verbally. Developing an objective and continuous tool ...


Candida auris: A quick review on identification, current treatments, and challe...

Cernáková, L.; Roudbary, M.; Brás, Susana; Tafaj, S.; Rodrigues, Célia F.

Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This rev...


Multimodal emotion evaluation: a physiological model for cost-effective emotion...

Pinto, Gisela; Carvalho, João M.; Barros, Filipa; Soares, Sandra C.; Pinho, Armando J.; Brás, Susana

Emotional responses are associated with distinct body alterations and are crucial to foster adaptive responses, well-being, and survival. Emotion identification may improve peoples' emotion regulation strategies and interaction with multiple life contexts. Several studies have investigated emotion classification systems, but most of them are based on the analysis of only one, a few, or isolated physiological si...



On the old story of the accidental pathogen: can transcriptomics clarify how S....

Brás, Susana; Cerca, Nuno; França, Ângela Maria Oliveira Sousa

Background: Staphylococcus epidermidis is a commensal inhabitant of healthy human skin and mucosae that can originate important infections such as medical device-associated bloodstream infections, often associated to patients with impaired or undeveloped immune systems. Of concern, the current inability to discriminate between true bacteraemia caused by S. epidermidis and contaminated blood cultures often leads...


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