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Multi-tissue transcriptomic-informed in silico investigation of drugs for the t...

Sierra, B; Magalhães, AC; Soares, D; Cavadas, B; Perez, AB; Alvarez, M; Aguirre, E; Bracho, C; Pereira, L; Guzman, MG

Transcriptomics, proteomics and pathogen-host interactomics data are being explored for the in silico–informed selection of drugs, prior to their functional evaluation. The effectiveness of this kind of strategy has been put to the test in the current COVID-19 pandemic, and it has been paying off, leading to a few drugs being rapidly repurposed as treatment against SARS-CoV-2 infection. Several neglected tropic...

Date: 2021   |   Origin: Repositório Aberto da Universidade do Porto
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