3 documents found, page 1 of 1
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
Hendrix, An; Lambein, Kathleen; Westbroek, Wendy; C Seabra, Miguel; Cocquyt, Veronique; Pauwels, Patrick; Bracke, Marc; Gespach, ChristianRegulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are medi...
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, ...
Hendrix, An; Maynard, Dawn; Pauwels, Patrick; Braems, Geert; Denys, Hannelore; Van Den Broecke, Rudy; Lambert, Jo; Van Belle, Simon; Cocquyt, VeroniqueBackground Secretory GTPases like Rab27B control vesicle exocytosis and deliver critical proinvasive growth regulators into the tumor microenvironment. The expression and role of Rab27B in breast cancer were unknown. Methods Expression of green fluorescent protein (GFP) fused with wild-type Rab3D, Rab27A, or Rab27B, or Rab27B point mutants defective in GTP/GDP binding or geranylgeranylation, or transient silenc...
The secretory small GTPase Rab27B as a marker for breast cancer progression.
Hendrix, A.; Braems, Geert; Bracke, Marc; C Seabra, Miguel; Gahl, William; De Wever, Olivier; Westbroek, WendyIn contemporary oncology practice, an urgent need remains to refine the prognostic assessment of breast cancer. It is still difficult to identify patients with early breast cancer who are likely to benefit from adjuvant chemotherapy. Although invasion of cancer cells is the main prognostic denominator in tumor malignancy, our molecular understanding and diagnosis are often inadequate to cope with this activity....