2 documents found, page 1 of 1
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, ...
Hendrix, An; Maynard, Dawn; Pauwels, Patrick; Braems, Geert; Denys, Hannelore; Van Den Broecke, Rudy; Lambert, Jo; Van Belle, Simon; Cocquyt, VeroniqueBackground Secretory GTPases like Rab27B control vesicle exocytosis and deliver critical proinvasive growth regulators into the tumor microenvironment. The expression and role of Rab27B in breast cancer were unknown. Methods Expression of green fluorescent protein (GFP) fused with wild-type Rab3D, Rab27A, or Rab27B, or Rab27B point mutants defective in GTP/GDP binding or geranylgeranylation, or transient silenc...
The secretory small GTPase Rab27B as a marker for breast cancer progression.
Hendrix, A.; Braems, Geert; Bracke, Marc; C Seabra, Miguel; Gahl, William; De Wever, Olivier; Westbroek, WendyIn contemporary oncology practice, an urgent need remains to refine the prognostic assessment of breast cancer. It is still difficult to identify patients with early breast cancer who are likely to benefit from adjuvant chemotherapy. Although invasion of cancer cells is the main prognostic denominator in tumor malignancy, our molecular understanding and diagnosis are often inadequate to cope with this activity....