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Canine visceral leishmaniasis : incidence and risk factors for infection in a c...
Vital, Wendel Coura; Reis, Alexandre Barbosa; Reis, Levi Eduardo Soares; Braga, Samuel Leôncio; Roatt, Bruno MendesZoonotic visceral leishmaniasis in Brazil is caused by Leishmania infantum parasites andis transmitted by sand flies of the Phlebotominae family. Dogs are the main urban reser-voirs and represent the major source of contagion for the vectors. Studies have shown thatmost infected dogs are polymerase chain reaction-positive months before seroconversion.Herein, we describe a cohort study designed to identify the i...
Performance of LBSap vaccine after intradermal challenge with L. infantum and s...
Roatt, Bruno Mendes; Soares, Rodrigo Dian de Oliveira Aguiar; Souza, Juliana Vitoriano de; Vital, Wendel Coura; Braga, Samuel LeôncioIn the last decade, the search for new vaccines against canine visceral leishmaniasis has intensified. However, the pattern related to immune protection during long periods after experimental infection in vaccine trials is still not fully understood. Herein, we investigated the immunogenicity and parasitological levels after intradermal challenge with Leishmania infantum plus salivary gland extract in dogs immu...
Profile of anti-Leishmania antibodies related to clinical picture in canine vis...
Freitas, José Cláudio Carneiro de; Lopes Neto, Belarmino Eugênio; Abreu, Cyntia Rafaelle Amaral de; Vital, Wendel Coura; Braga, Samuel LeôncioThis research investigated the profile of anti-Leishmania antibodies in different clinical forms of canine visceral leishmaniasis (CVL). Naturally infected dogs were divided into two groups: subclinical dogs (SD, n = 10) and clinical dogs (CD, n = 68). Non-infected dogs (ND, n = 7) comprised the negative control group. The humoral response was evaluated by the profile of total IgG, IgG1, IgG2, IgM, IgA and IgE,...
Caracterização biológica, bioquímica e molecular em isolados de Leishmania infa...
Braga, Samuel LeôncioNo Brasil, a Leishmaniose Visceral Canina (LVC) é causada por Leishmania infantum e os cães tem sido considerados como os principais responsáveis pela dispersão da doença. A LVC pode se manifestar com diferentes formas clínicas, variando desde uma infecção de caráter assintomático até uma forma sintomática grave, a qual na maioria das vezes culmina com a morte dos animais. O presente estudo empregou ferramentas...
Prevalence and factors associated with leishmania infantum infection of dogs fr...
Vital, Wendel Coura; Marques, Marcos José; Veloso, Vanja Maria; Roatt, Bruno Mendes; Soares, Rodrigo Dian de Oliveira Aguiar; Reis, Levi Eduardo SoaresVisceral leishmaniasis (VL) is a disease caused by the parasite Leishmania infantum , and dogs are the most important domestic reservoirs of the agent. During recent decades, VL has expanded to large Brazilian urban centers. In the present work, we have demonstrated by using molecular techniques that the rate of canine infection as detected by serology has been considerably underesti mated. Two groups of serone...