3 documents found, page 1 of 1
Screening and antifungal activity of a β-carboline derivative against cryptococ...
Cruz, Kátia Santana; Lima, Emerson Silva; Silva, Marcia de Jesus Amazonas da; Souza, Érica Simplício de; Montoia, Andréia; Pohlit, Adrian MartinBackground. Cryptococcosis is a fungal disease of bad prognosis due to its pathogenicity and the toxicity of the drugs used for its treatment. The aim of this study was to investigate the medicinal potential of carbazole and β-carboline alkaloids and derivatives against Cryptococcus neoformans and C. gattii. Methods. MICs were established in accordance with the recommendations of the Clinical and Laboratory Sta...
Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ...
Silva, Luiz Francisco Rocha e; Montoia, Andréia; Amorim, Rodrigo C.N.; Melo, Márcia R.S.; Henrique, Marycleuma Campos; Nunomura, Sergio MassayoshiIndole alkaloids ellipticine (1), cryptolepine triflate (2a), rationally designed 11-(4-piperidinamino)cryptolepine hydrogen dichloride (2b) and olivacine (3) (an isomer of 1) were evaluated in vitro against Plasmodium falciparum and in vivo in Plasmodium berghei-infected mice. 1-3 inhibited P. falciparum (IC50 ≤ 1.4 μM, order of activity: 2b > 1 > 2a > 3). In vitro toxicity to murine macrophages was evaluated ...
Antimalarial activity of ellipticine
Pohlit, Adrian Martin; Silva, Luiz Francisco Rocha e; Henrique, Marycleuma Campos; Montoia, Andréia; Amorim, Rodrigo César das Neves