5 documents found, page 1 of 1
Fibroblasts Impair Migration and Antitumor Activity of NK-92 Lymphocytes in a M...
Iaia, Ilenia; Brancato, Virginia; Caballero, David; Reis, R. L.; Aglietta, Massimo; Sangiolo, Dario; Kundu, Subhas CAdoptive cell therapy in solid tumors, such as melanoma, is impaired, but little is known about the role that the fibroblasts present in the tumor microenvironment could exert. However, the mechanism at play is not well understood, partly due to the lack of relevant pre-clinical models. Three-dimensional culture and microfluidic chips are used to recapitulate the dynamic interactions among different types of ce...
Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and ...
Petroni, Simona; Tagliaro, Irene; Antonini, Carlo; D'Arienzo, Massimiliano; Orsini, Sara Fernanda; Mano, João F; Brancato, Virginia; Borges, JoãoChitosan is a marine-origin polysaccharide obtained from the deacetylation of chitin, the main component of crustaceans' exoskeleton, and the second most abundant in nature. Although this biopolymer has received limited attention for several decades right after its discovery, since the new millennium chitosan has emerged owing to its physicochemical, structural and biological properties, multifunctionalities an...
AdipoSIGHT in therapeutic response: consequences in osteosarcoma treatment
Kundu, Banani; Brancato, Virginia; Oliveira, Joaquim; Correlo, V. M.; Reis, R. L.; Kundu, Subhas CChemotherapeutic resistance is a major problem in effective cancer treatment. Cancer cells engage various cells or mechanisms to resist anti-cancer therapeutics, which results in metastasis and the recurrence of disease. Considering the cellular heterogeneity of cancer stroma, the involvement of stem cells is reported to affect the proliferation and metastasis of osteosarcoma. Hence, the duo (osteosarcoma: Saos...
Convection patterns gradients of non-living and living micro-entities in hydrogels
Canadas, Raphael Faustino; Patrício, Pedro; Brancato, Virginia; Gasperini, Luca; Caballero, David; Pires, Ricardo A; Costa, João B.; Pereira, HélderInducing thermal gradients in two injected fluid systems results in the temporal formation of mixing conductive streams. If preserved through sol-gel transition, this mechanism can be used to drive and pattern non-living and living entities in mixed hydrogels. Interfaces are vital in nature, where gradients of non-living and living entities build distinct yet continuous integrated living tissues. However, the c...
Convection patterns gradients of non-living and living micro-entities in hydrogels
Canadas, Raphaël F.; Patricio, Pedro; Brancato, Virginia; Gasperini, Luca; Caballero, David; Pires, Ricardo A.; Costa, João; Pereira, Hélder; Yong, PingInducing thermal gradients in two injected fluid systems results in the temporal formation of mixing conductive streams. If preserved through sol-gel transition, this mechanism can be used to drive and pattern non-living and living entities in mixed hydrogels. Interfaces are vital in nature, where gradients of non-living and living entities build distinct yet continuous integrated living tissues. However, the c...