Hiccups are a very uncomfortable experience for palliative care patients and can greatly impact their quality of life.Physical manoeuvres can often terminate acute hiccups. Persistent and intractable hiccups that continue for progresdays or months are rare and difficult to treat. In situations where no reversible cause is identified, or where physical manoeuvres have failed, a systematic approach is required.Th...
Esophageal squamous cell carcinoma (ESCC) poses a significant health burden in Mozambique, with high incidence rates and late-stage diagnoses contributing to its lethality. This comprehensive review examines the epidemiology, risk factors, and potential preventive strategies for ESCC in Mozambique. Key risk factors identified include tobacco smoking, alcohol consumption, dietary factors, hot beverage consumptio...
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Objective: Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour. Design: We have studied the spontaneous flow of extracellular vesicles (EVs) between subpopulations of cancer cells: cancer stem cells (CSC) and non-stem cancer cells (NSCC). To determine th...
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Introduction: Failure in Transfer of Passive Immunity (FTPI) is a condition that occurs frequently in the bovine species when inadequate ingestion or absorption of enough good-quality colostrum takes place. In bovine kept in extensive conditions, FTPI diagnosis is usually made by complete physical examination, with not enough time for laboratory analysis, and treatment is based on the administration of colostru...
Introduction: Failure in Transfer of Passive Immunity (FTPI) is a condition that occurs frequently in the bovine species when inadequate ingestion or absorption of enough good-quality colostrum takes place. In bovine kept in extensive conditions, FTPI diagnosis is usually made by complete physical examination, with not enough time for laboratory analysis, and treatment is based on the administration of colostru...
Background: Endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is recommended for diagnosis of pancreatic cystic lesions (PCLs). Its role in surveillance is unclear. Our goal was to determine if a second EUS-FNA changes diagnosis or management of PCLs. Methods: A retrospective analysis of an EUS database, searching for EUS-FNAs in PCLs from 2007 to 2017 was performed. Demographics, cyst characteristics...
This work aims to assess whether the biochemical response of radium-223-dichloride treatment can be predicted based on the pretherapy bone scan, and consequently, if bone scan index (BSI) and maximum lesion intensity have a place as alternatives or as complements to extent of bone disease (EOBD) scoring in predicting biochemical response to treatment. Many cases of advanced prostate cancer have evidence of bone...
The Austronesian dispersal across the Indonesian Ocean to Madagascar and the Comoros has been well documented, but in an unexplained anomaly, few to no traces have been found of the Austronesian expansion in East Africa or the Arabian Peninsula. To revisit this peculiarity, we surveyed the Western Indian Ocean rim populations to identify potential Austronesian genetic ancestry. We generated full mitochondrial D...