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Myocardial Work Brings New Insights into Left Ventricular Remodelling in Cardio...

Vaz Ferreira, V; Mano, T; Cardoso, I; Coutinho Cruz, M; Branco, LM; Almeida-Morais, L; Timóteo, AT; Galrinho, A; Castelo, A; Garcia Brás, P; Simão, D

Serial transthoracic echocardiographic (TTE) assessment of 2D left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) are the gold standard screening methods for cancer therapeutics-related cardiac dysfunction (CTRCD). Non-invasive left ventricular (LV) pressure-strain loop (PSL) provides a novel method of quantifying myocardial work (MW) with potential advantages to evaluate the impact o...


Quality of Life Among Adults with Repaired Tetralogy of Fallot: a Literature Re...

Rodrigues, C; Silva, M; Cerejo, R; Rodrigues, R; Sousa, L; Trigo, C; Branco, LM; Agapito, A; Fragata, J

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect. Survival into adulthood is currently expected following surgical repair, leading to a growing population of adults with repaired TOF. In this literature review, we aim to summarize the current state of knowledge on the quality of life of adults with repaired TOF. A search was conducted on PubMed and results were reviewed for articles...


Prevalence and Prognostic Impact of Apical Sparing Contractility Pattern in Pat...

Ferreira, V; Aguiar Rosa, S; Pereira-da-Silva, T; Rodrigues, I; Gonçalves, A; Mendonça, T; Castelo, A; Branco, LM; Galrinho, A; Fiarresga, A; Ramos, R

Introduction: Prolonged afterload increase in aortic stenosis (AS) may alter left ventricular (LV) contractility, irrespective of LV ejection fraction (LVEF). The prevalence and morbimortality associated with the apical sparing strain pattern (ASP), a typical finding of cardiac amyloidosis (CA), are not fully understood in patients with AS. We assessed the prevalence of the ASP in patients with severe AS and it...


Three-Dimensional Speckle-Tracking Echocardiography for the Global and Regional...

Coutinho Cruz, M; Branco, LM; Portugal, G; Galrinho, A; Timóteo, AT; Rio, P; Ilhão Moreira, R; Mendonça, T; Leal, A; Gameiro, F; Duarte Oliveira, S

Background: Assessment of 2D/3D left ventricular ejection fraction (LVEF) and 2D global longitudinal strain (GLS) is the gold standard for diagnosing cancer therapeutics-related cardiac dysfunction (CTRCD). Although 3D speckle-tracking echocardiography (STE) has several advantages, it is not used in this setting. Methods: 105 breast cancer patients who underwent serial echocardiographic assessment during anthra...


Cardiotoxicity in Breast Cancer Treatment: What About Left Ventricular Diastoli...

Timóteo, AT; Branco, LM; Filipe, F; Galrinho, A; Rio, P; Portugal, G; Oliveira, S; Cruz Ferreira, R

Aims: Cardiotoxicity is a possible complication of cancer treatment, particularly with anthracyclines and anti-HER2 drugs. Systolic dysfunction has already been described. Diastolic dysfunction and left atrial function are less studied. We sought to analyze the impact of cardiotoxic treatments on left ventricular diastolic function and left atrial (LA) function. Methods and results: Retrospective study of 100 p...


Antiarrhythmic Effect of Sacubitril-Valsartan: Cause or Consequence of Clinical...

Valentim Gonçalves, A; Pereira-da-Silva, T; Galrinho, A; Rio, P; Branco, LM; Soares, R; Feliciano, J; Ilhão Moreira, R; Cruz Ferreira, R

Sacubitril/Valsartan (LCZ696) reduced sudden cardiac death in the PARADIGM-HF trial. However, the mechanism by which LCZ696 reduces ventricular arrhythmias remains unclear. The aim of this study was to compare electrocardiographic (ECG) parameters and mechanical dispersion index, assessed by left ventricular (LV) global longitudinal strain (GLS), before and after LCZ696 therapy. We prospectively evaluated chron...


Short- and Long-Term Outcome After Alcohol Septal Ablation in Obstructive Hyper...

Aguiar Rosa, S; Fiarresga, A; Galrinho, A; Cacela, D; Ramos, R; de Sousa, L; Gonçalves, A; Bernardes, L; Patrício, L; Branco, LM; Cruz Ferreira, R

Introduction: In obstructive hypertrophic cardiomyopathy (HCM), alcohol septal ablation (ASA) can lead to gradient reduction and symptom improvement. We aimed to assess the efficacy and safety of ASA in a long-term outcome study. Methods: We analyzed patients who underwent ASA over a seven-year period in a tertiary center. The primary echocardiographic endpoint was >50% reduction in left ventricular outflow tra...


Response and Outcomes of Cardiac Resynchronization Therapy in Patients with Ren...

Ilhão Moreira, R; Cunha, PS; Rio, P; Nogueira da Silva, M; Branco, LM; Galrinho, A; Feliciano, J; Soares, R; Cruz Ferreira, R; Oliveira, MM

PURPOSE: Renal dysfunction is often associated with chronic heart failure, leading to increased morbi-mortality. However, data regarding these patients after cardiac resynchronization therapy (CRT) is sparse. We sought to evaluate response and long-term mortality in patients with heart failure and renal dysfunction and assess renal improvement after CRT. METHODS: We analyzed 178 consecutive patients who underwe...


Infective Endocarditis: Surgical Management and Prognostic Predictors

Ilhão Moreira, R; Coutinho Cruz, M; Branco, LM; Galrinho, A; Coutinho Miranda, L; Fragata, J; Cruz Ferreira, R

INTRODUCTION AND AIM: Infective endocarditis (IE) is associated with high morbidity and mortality. It is important to determine which factors increase the risk of poor outcome in order to enable early detection and aggressive treatment, including surgery. The aim of our study was to identify factors predicting complications and in-hospital mortality in patients with IE and to analyze conditions predisposing to ...


Does Permanent Atrial Fibrillation Modify Response to Cardiac Resynchronization...

Abreu, A; Oliveira, MM; Cunha, PS; Santa Clara, H; Portugal, G; Rodrigues, I; Santos, V; Almeida-Morais, L; Selas, M; Soares, R; Branco, LM

INTRODUCTION: The benefits of cardiac resynchronization therapy (CRT) documented in heart failure (HF) may be influenced by atrial fibrillation (AF). We aimed to compare CRT response in patients in AF and in sinus rhythm (SR). METHODS: We prospectively studied 101 HF patients treated by CRT. Rates of clinical, echocardiographic and functional response, baseline NYHA class and variation, left ventricular ejectio...


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