19 documents found, page 1 of 2
A GIS-Based Approach to Fostering Sustainable Mobility and Combating Social Iso...
Branco, Luís; Santos, BerthaThe growing demographic trend of an aging population, particularly in remote rural areas, exacerbates social isolation and limits access to essential goods and services. This vulnerability highlights a pressing need to develop sustainable solutions for their mobility and support. Using Geographic Information Systems (GISs) and network analysis, a workflow was developed to optimize road-based transport for the e...
Mapeamento de incêndios e caracterização geral do território a partir de Deteçã...
Branco, LuísOs incêndios florestais devem constituir-se como uma preocupação para as entidades governamentais, mas também para todos os cidadãos, pois, com exceção dos programados, podem provocar prejuízos de natureza variada impactando significativamente nas populações. A análise dos eventos passados é necessária tanto na ótica da prevenção como no inventário das consequências desses eventos. Para isso, torna-se determina...
In Vitro Antimicrobial Studies of Mesoporous Silica Nanoparticles Comprising An...
Filipe, Luís; Sousa, Telma; Silva, Dário; Santos, Miguel; Ribeiro Carrott, Manuela; Poeta, Patrícia; Branco, Luís; Gago, SandraThe combination of active pharmaceutical ingredients in the form of ionic liquids or organic salts (API-OSILs) with mesoporous silica nanoparticles (MSNs) as drug carriers can provide a useful tool in enhancing the capabilities of current antibiotics, especially against resistant strains of bacteria. In this publication, the preparation of a set of three nanomaterials based on the modification of a MSN surface ...
When passion is not enough: a study on how a football club can tackle inflation...
Branco, LuísThe football industry has developed significantly over the past few decades and evolved into something more complicated than merely entertainment or sports. SL Benfica is one of the most successful sports organizations in Portugal and Europe, however the Club is not indifferent to the disruption and trends of the labor market. The goal of this dissertation was to identify approaches that may be used to address ...
Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis,...
Forte, Andreia; Gago, Sandra; Ribeiro Carrott, Manuela; Carrott, Peter; Alves, Celso; Teodoro, Fernando; Pedrosa, Rui; Marrucho, Isabel; Branco, LuísSeveral organic salts based on the combination of two different choline derivative cations and [MnCl3]-, [GdCl4]- and [TbCl4]- as anions, were immobilized in mesoporous silica nanoparticles (MSNs) by a two-step synthetic method. Firstly, MSNs were functionalized with choline derivative cations with chloride anions and then the metals were incorporated by the reaction of the chloride with the respective metal ch...
Highlighting the biological potential of the brown seaweed Fucus spiralis for s...
Freitas, Rafaela; Martins, Alice; Silva, Joana; Alves, Celso; Pinteus, Susete; Alves, Joana; Teodoro, Fernando; Ribeiro, Helena MargaridaSkin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revea...
Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for S...
Freitas, Rafaela; Martins, Alice; Silva, Joana; Alves, Celso; Pinteus, Susete; Alves, Joana; Teodoro, Fernando; Ribeiro, Helena MargaridaSkin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revea...
Bisphosphonates and cancer: a relationship beyond the antiresorptive effects
Teixeira, Sónia; Branco, Luís; Fernandes, Maria H.; Costa-Rodrigues, JoãoBisphosphonates (BPs) are stable analogues of the Inorganic Pyrophosphate (PPi), an endogenous regulator of bone mineralization, which can resist the hydrolysis in the gastrointestinal tract. Their conformation allows targeting the bone as a result of their three-dimensional structure, which makes them primary agents against osteoclast-mediated bone loss. They are used in many bone pathological conditions, like...
Etidronate-based ionic liquids: in vitro effects on bone metabolism
Teixeira, Sónia; Santos, Miguel; Branco, Luís; Fernandes, Maria Helena; Costa-Rodrigues, JoãoThe Bisphosphonates have been used for various purposes since the middle of the 19th century, but the propriety that elicited more curiosity was their ability to regulate bone mineralization. This characteristic made this drug the elite choice for treatments of several pathologies associated to increased bone resorption.
Evaluation of solubility and partition properties of ampicillin-based ionic liq...
Florindo, Catarina; Araújo, João; Alves, Filipa; Matos, Carla; Ferraz, Ricardo; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoIn order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected fr...