3 documents found, page 1 of 1
Lanthanide-based organic salts: Synthesis, characterization, and cytotoxicity s...
Forte, Andreia; Gago, Sandra; Alves, Celso; Silva, Joana; Pedrosa, Rui; Laia, César A.T.; Marrucho, Isabel M.; Branco, Luis C.The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. Th...
Synthesis and biological evaluation of Amphotericin B formulations based on org...
Ferraz, Ricardo; Santarém, Nuno; Santos, Andreia F. M.; Jacinto, Manuel L.; Cordeiro-da-Silva, Anabela; Prudêncio, Cristina; Noronha, João PauloNowadays, organic salts and ionic liquids (OSILs) containing active pharmaceutical ingredients (APIs) are being explored as drug delivery systems in modern therapies (OSILs-API). In that sense, this work is focused on the development of novel OSILs-API based on amphotericin B through an innovative procedure and the evaluation of the respective biological activity against Leishmania infantum. Several ammonium, m...
More Sustainable Approaches for the Synthesis of N-Based Heterocycles
Candeias, Nuno R.; Branco, Luis C.; Gois, Pedro M. P.; Afonso, Carlos A. M.; Trindade, Alexandre F.Fundacao para a Ciencia e Tecnologia ; FEDER [POCI/QUI/60175/2004, PTDC/QUI/(66015)(66826)(66695)-(70383)(70902)(73061)/2006)]. - We would like to thank Fundacao para a Ciencia e Tecnologia, (POCI 2010) and FEDER (Ref. POCI/QUI/60175/2004, PTDC/QUI/(66015)(66826)(66695)-(70383)(70902)(73061)/2006) for financial support.