15 documents found, page 1 of 2
Trajectories of cognitive performance over five years in a prospective cohort o...
Araújo, N; Severo, M; Lopes-Conceição, L; Fontes, F; Dias, T; Branco, M; Morais, S; Cruz, VT; Ruano, L; Pereira, S; Lunet, NPurpose To identify trajectories of cognitive performance up to five years since diagnosis and their predictors, in a cohort of patients with breast cancer (BCa). Methods A total of 464 women with BCa admitted to the Portuguese Institute of Oncology, Porto, during 2012, were evaluated with the Montreal Cognitive Assessment (MoCA) before any treatment, and after one, three and five years. Probable cognitive impa...
Determinants of age at onset in a Portuguese cohort of autosomal dominant spast...
Rodrigues, R; Silva, R; Branco, M; Brandão, E; Alonso, I; Ruano, L; Loureiro, JLBackground Hereditary spastic paraplegias present a high variability of age at onset, ranging from childhood to older age. Our objective was to identify the determinants of age at onset in autosomal dominant HSP (AD-HSP) in a large cohort of patients and families. Methods We included 239 patients from 89 families identified in the Portuguese multisource population-based survey of hereditary ataxias and spastic ...
Tracking cognitive impairment in multiple sclerosis using the Brain on Track te...
Ruano, L; Branco, M; Severo, M; Sousa, A; Castelo, J; Araújo, I; Pais, J; Cerqueira, J; Amato, MP; Lunet, N; Cruz, VTBackground: The accurate and regular monitoring cognitive performance in multiple sclerosis (MS) patients is critical to develop new prevention and management strategies for cognitive impairment (CI). The Brain on Track (BoT) test is a self-administered web-based tool developed for cognitive screening and monitoring. The objective of this study was to validate the use of the BoT in MS, by assessing its ability ...
The epidemiology of multiple sclerosis in the entre Douro e Vouga region of nor...
Branco, M; Alves, I; Martins, de Silva, A; Pinheiro, J; Sá, MJ; Correia, I; Sousa, L; Brandão, E; Veira, C; Gomes, B; Ruano, LBackground. The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north–south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed in Portugal have reported a lower prevalence than the average for Western Europe. The aim of this study is to estimate the prevalence of MS in the Entre Douro e Vouga region, in Northern Portug...
Aging with multiple sclerosis: prevalence and profile of cognitive impairment
Branco, M; Ruano, L; Portaccio, E; Goretti, B; Niccolai, C; Patti, F; Chisari, C; Gallo, P; Grossi, P; Ghezzi, A; Roscio, M; Mattioli, F; Bellomi, FBackground The increase in life expectancy of patients with multiple sclerosis (MS) requires a better knowledge of disease features in the older patients group. Objective To describe the prevalence and profile of cognitive impairment (CI) in older patients with MS and perform a comparison with younger patients. Methods Patients were consecutively recruited for 6 months. Cognitive performance was assessed throug...
Tracking Cognitive Performance in the General Population and in Patients with M...
Ruano, L; Severo, M; Sousa, A; Ruano, C; Branco, M; Barreto, R; Moreira, S; Araújo, N; Pinto, P; Pais, J; Lunet, N; Cruz, VTRepeated measurements could be helpful to identify patients with early cognitive decline. We compare the variation of cognitive performance over one year in patients with mild cognitive impairment (MCI) and healthy individuals using the Brain on Track self-applied computerized test (BoT). The study was initiated 30 patients with probable MCI and 377 controls from a population-based cohort, who performed the BoT...
Prevalence and Causes of Cognitive Impairment and Dementia in a Population-Base...
Ruano, L; Araújo, N; Branco, M; Barreto, R; Moreira, S; Pais, R; Cruz, VT; Lunet, N; Barros, HBackground: Vascular disease may play an important role in the epidemiology of dementia in countries with high stroke incidence, such as Portugal. Objective: To assess the prevalence and etiology of cognitive impairment in a population-based cohort from Portugal. Methods: Individuals ≥55 years (n = 730) from the EPIPorto cohort were assessed using the Mini-Mental State Examination and the Montreal Cognitive Ass...
Psychopathological dimensions in subjects with hereditary ATTR V30M amyloidosis...
Lopes, A; Fonseca, I; Sousa, A; Rodrigues, C; Branco, M; Coelho, T; Sequeiros, J; Freitas, PBackground: Chronic physical illness has been associated with emotional distress. Chronic diseases may change usual family patterns with economic, social and family losses. Hereditary ATTR V30M amyloidosis is a rare, fatal inherited systemic amyloidosis, with chronic evolution and beginning in adulthood. Aims and methods: To evaluate psychopathological dimensions and how they correlated with disease-related lif...
Family dynamics in transthyretin-related familial amyloid polyneuropathy Val30M...
Lopes, A; Rodrigues, C; Fonseca, I; Sousa, A; Branco, M; Coelho, T; Sequeiros, J; Freitas, PAdult-onset, chronic, genetic diseases like transthyretin-related familial amyloid polyneuropathy Val30Met (TTR-FAP Val30Met), have a major psychosocial impact not only on patients, but also on families. Genetic risk may therefore be an increased factor in psychosocial impact of the disease on these families' functioning. To evaluate impact of genetic risk, a study was conducted to perceive the impact of the il...
Life paths of patients with transthyretin-related familial amyloid polyneuropat...
Lopes, A; Sousa, A; Fonseca, I; Branco, M; Rodrigues, C; Coelho, T; Sequeiros, J; Freitas, PTransthyretin-related familial amyloid polyneuropathy Val30Met is a fatal progressive disease. It is a rare hereditary amyloidosis, manifesting as a sensorimotor neuropathy and autonomic dysfunction. It begins during adulthood and is a disabling disease, posing a great psychological burden to patients and their families. Our aim was to describe and characterize life events related to the disease and discuss its...