96 documents found, page 1 of 10
C135. PERITONEAL DIALYSIS EFFLUENT-DERIVED MESOTHELIAL CELLS AS A MODEL TO STUD...
Sequeira, Diogo; Teixeira-Santos, Luísa; Anão, Sofia; Pimpão, António B.; Calça, Rita; Monteiro, Emília; Branco, Patrícia; Sousa, CátiaIntroduction: Peritoneal dialysis (PD) is a home-based renal replacement therapy that relies on the dialytic properties of the peritoneal membrane [1]. However, progressive membrane dysfunction, mesothelial-to-mesenchymal transition events and fibrosis remain major limitations to long-term PD success [2]. The aryl hydrocarbon receptor (AhR) is a ligand activator transcription factor that has been implicated in ...
A THIOL BASED TOOL TO EXPLORE PERITONEAL MEMBRANE PROTECTIVE DRUG CANDIDATES
Anão, Sofia; Teixeira-Santos, Luísa; Sequeira, Diogo; Sousa, Cátia; Gonçalves, Joana; Monteiro, Emília C.; Calça, Rita; Branco, PatríciaIntroduction: Peritoneal dialysis (PD) is a renal replacement therapy that offers several advantages, including greater patient autonomy. However, peritoneal membrane fibrosis and loss of membrane integrity remain the main limiting factors for the long-term success of PD [1]. At SPF 2024, our group reported an association between peritoneal membrane fibrosis and aminothiol levels, namely cysteine, in PD effluen...
The PDE-thiolome as an indicator of Peritoneal Membrane vulnerability
Sequeira, Diogo; Teixeira-Santos, Luísa; Anão, Sofia; Sousa, Cátia; Monteiro, Emília; Calça, Rita Ribeiro; Branco, Patrícia; Pereira, Sofia A.Background and Aims: Peritoneal membrane health is crucial for peritoneal dialysis effectiveness [1]. Strategies to overcome peritoneal membrane (PM) injury and fibrosis remain an unmet need in PD, due to many factors [2]. Among these is the lack of early indicators to identify patients at higher risk before structural damage becomes irreversible. While oxidative stress is recognized as an early trigger in fibr...
Multi-thiol assessment upon the Peritoneal Equilibration Test (PET) reveals sol...
Anão, Sofia; Sequeira, Diogo; Calça, Rita; Gonçalves, Joana; Sousa, Cátia; Branco, Patrícia; Pereira, Sofia A.; Teixeira-Santos, LuísaPeritoneal membrane (PM) dysfunction remains a key limitation to the long-term efficacy of peritoneal dialysis (PD) [1]. The Peritoneal Equilibration Test (PET), widely used to clinically assess PM function, primarily evaluates creatinine transport but may overlook distinct membrane response patterns. Aminothiols such as cysteine (Cys), homocysteine (HCys), cysteinylglycine (CysGly), and glutathione (GSH), a th...
(Re)inventing the house of justice: from courthouse buildings to the metaverse
Branco, Patrícia; Casaleiro, Paula; Dias, João PauloOs edifícios dos tribunais são definidos como ambientes simbólicos e ritualísticos nos quais as pessoas experimentam a autoridade judicial. Com a eclosão da pandemia de covid-19, o acesso aos espaços físicos dos tribunais foi severamente limitado, ao mesmo tempo em que se verificou um aumento na utilização de ferramentas digitais e de trabalho remoto. A utilização e/ou o desenvolvimento de tecnologias digitais ...
Assessing the potential of brewer’s spent grain to enhance cookie physicochemic...
Nicolai, Marisa; Palma, Maria Lídia; Reis, Ricardo; Amaro, Rúben; Fernandes, Jaime; Gonçalves, Elsa M.; Silva, Mafalda; Lageiro, ManuelaBrewers’ spent grain (BSG), the major by-product of the brewery industry, has high nutritional value, making it suitable for upcycling into products such as healthy, and sustainable cookies. Nonetheless, the incorporation of BSG in cookies can impact their quality, given the increased fiber and protein content. This work explored the effect of replacing wheat flour with BSG at 50% and 75% in cookie formulations...
Disaster Nephrology in Portugal: A Call for National Preparedness
Guerra, Maria Manuel; Santos, Diana; Roxo, Maria Inês; Pepe, Bruno; Santos, Luís; Figueiredo Martins, João; Moreira Fonseca, Nuno; Branco, Patrícia.
Multidisciplinary cardiorenal program for heart failure patients: Improving out...
Calça, Rita; Malho, Anabela; Domingos, Ana Teresa; Fernandes, Raquel Menezes; Silva, Francisca Gomes da; Aguiar, Carlos; Tralhão, AntónioThe cardiorenal program (CRP), implemented within a specialized heart failure and kidney disease clinic, encompasses a multidisciplinary approach to the management of patients with heart failure and kidney disease. It focuses on optimizing therapy and improving patient outcomes. The CRP includes a range of services, including clinical evaluation, diagnostic testing, medical treatment, and patient education. The...
Hyperkalemia management: a multidisciplinary expert panel’s perspective on the ...
Fonseca, Cândida; Garagarza, Cristina; Silva, Gil; Caires, Graça; Marques, Irene; Lopes, José António; Branco, Patrícia; Alves, Rui; Ferreira, AníbalHyperkalemia is a potentially life-threatening condition frequently encountered in clinical practice, particularly among patients with chronic kidney disease, heart failure, diabetes, and hypertension and those undergoing treatment with renin-angiotensin-aldosterone system inhibitors (RAASi). The management of chronic and acute hyperkalemia is complex and requires timely intervention to prevent severe complicat...
Analysing courthouses’ spaces, places and architecture: Some methodological out...
Branco, PatríciaThe aim of this article is to retrospectively reflect on my experiences conducting research on the intersections between courthouse architecture and access to justice in family and children's matters. This raises methodological and practical issues motivated by the novelty of the theme, as was the case when I began my doctoral research approximately 13 years ago, in Portugal. Therefore, I will discuss the strat...