5 documents found, page 1 of 1
The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein ...
Marinho, Aline T.; Batuca, Joana R.; Miranda, Joana P.; Caixas, Umbelina; Dias, Clara G.; Branco, Teresa; Soto, Karina; Pinheiro, PedroThe antiretroviral nevirapine (NVP) is associated to a reduction of atherosclerotic lesions and increases in high-density lipoprotein (HDL)-cholesterol. Despite being a hepatotoxic drug, which forbids its re-purposing to other therapeutic areas, not all NVP metabolites have the same potential to induce toxicity. Our aim was to investigate the effects of NVP and its metabolites in an exploratory study, towards t...
Development of the HIV360 international core set of outcome measures for adults...
Marques‐Gomes, João; Salt, Matthew J.; Pereira‐Neto, Rita; Barteldes, Franca S.; Gouveia‐Barros, Vera; Carvalho, AlexandreObjectives: HIV outcomes centre primarily around clinical markers with limited focus on patient-reported outcomes. With a global trend towards capturing the outcomes that matter most to patients, there is agreement that standardizing the definition of value in HIV care is key to their incorporation. This study aims to address the lack of routine, standardized data in HIV care. Methods: An international working ...
Neck circumference is associated with adipose tissue content in thigh skeletal ...
Tellez, Maria Jose Arias; Silva, Analiza M; Ruiz, Jonatan R.; Martins, Sandra S.; Palmeira, António Labisa; Branco, Teresa; Minderico, CláudiaNeck circumference (NC) has been proposed as a simple and practical tool, independently associated with cardiometabolic risk factors. However, the association of NC with inter-muscular adipose tissue (IMAT) is still to be determined. We aimed to examine the association of NC with thigh IMAT, and visceral adipose tissue (VAT) measured with computed tomography (CT) in overweight/obese women. 142 premenopausal ove...
Hepatitis C in drug addicts: access and treatment compliance.
Sarmento E Castro, Rui; Valente, Cristina; Ramos, José Presa; Almeida, José Rocha; Marinho, Rui Tato; Branco, Teresa; Andrade, Sofia; Macedo, AnaCurrently, hepatitis C is a serious public health problem. It is estimated that there are 180 million people with chronic infection by hepatitis C virus (HCV) worldwide and that the prevalence of this infection in the Portuguese population ranges between 1 and 1.5%. In Portugal, there are neither up-to-date guidelines for treatment, nor recommendations for the diagnosis and management of patients with HCV and, ...
Analysis of mediation and reciprocal effects of changes in weight, self-esteem,...
Palmeira, António Labisa; Teixeira, Pedro J.; Silva, Marlene N.; Markland, David; Branco, Teresa; Martins, Sandra; Minderico, C. S.; Serpa, Sidónio O.Improving the treatment of obesity remains a critical challenge. Several health behaviour change models, often based on a social-cognitive framework, have been used to design weight management interventions (Baranowski et al., 2003). However, most interventions have only produced modest weight reductions (Wadden et al., 2002) and socialcognitive variables have shown limited power to predict weight outcomes (Pal...