67 documents found, page 1 of 7

Being-centred design – notes on a speculative process philosophy

This paper introduces Being-Centred Design (BCD) as a speculative approach that moves beyond prevalent user- and human-centred models towards a focus on human existence and profound experiences. Rooted in Providência’s triangular framework of authorship, programme, and technology, BCD advocates for an approach that balances practicality and existential meaning in creative production. At the core of BCD’s underl...

Exposure of human glioblastoma cells to thimerosal inhibits the thioredoxin sys...

Glioblastoma multiforme (GBM) is the most common, aggressive, and fatal primary malignant brain tumor in adults. The therapeutic efficacy of temozolomide (TMZ) is limited owing to frequent treatment resistance. The latter is in part related to the overexpression of redox systems such as the thioredoxin system. This system is fundamental for cell survival and proliferation, regulating hypoxia inducible factor-1a...

Guiding principles of interaction and usability for the development of a Archit...

The Cycle of Linen is an ancient tradition of linen making in Portugal that is practically extinct but which survives in the Caramulo mountain range, thanks to the skill and resilience of the artisans of the AmaCastelões association.This article describes the participant observation phase of a doctoral research project in design which focuses on identifying specialities and specificities that could contribute f...

Objective structured clinical/practical examination (OSC/PE) in pharmaceutical ...

Objective Structured Clinical/Practical Examination (OSC/PE) in Pharmaceutical ...

Interaction of Polycyclic Aromatic Hydrocarbon compounds in fish primary hepato...

Polycyclic Aromatic Hydrocarbons (PAHs) are persistent pollutants normally found in the environment as complex mixtures. Although several individual PAHs are classified as mutagenic and carcinogenic pollutants, the interaction effects between compounds in a mixture may trigger different toxicological mechanisms and, consequently, yield different effects to organisms which are not accounted for in risk assessmen...

Nanoplastics activate a TLR4/p38-mediated pro-inflammatory response in human in...

The crescent presence of nanoplastics in the environment raises concerns regarding their potential impact on health. This study exposed human colon adenocarcinoma cells (HT29) and microglia cells (N9) to nanoplastics (25 nm, 50 nm, and 100 nm Polystyrene) to investigate their inflammatory responses, which are vital for body's defence. Although cytotoxicity remained generally low, HT29 cells exhibited a notable ...

Challenges and opportunities in combining physicalization with augmented realit...

Data is the new “natural resource” of the 21st century. Recent years have witnessed its rapid expansion, increasing the production and availability of data. In this context, there are still significant challenges to fully realizing its potential, especially to make it accessible and more useful to the larger public. Considering design as an activity of cultural mediation and since “data has no naturally corresp...

Mapping Portugal's design landscape: findings, challenges and future research d...

The closure of the Portuguese Design Center in 2013, left Portugal with no instruments of mediation between the Portuguese design ecosystem and the socio-economic fabric. DesignOBS (Towards a design observatory in Portugal) - a research project aiming to identify, map and interpret the Portuguese design landscape (2019-2022), aimed to tackle this issue via the development and application of a distributed and pa...

Editorial: Redox-signaling in neurodegenerative diseases: biomarkers, targets, ...