Isthmocele is a growing pathology due to the increase in the number of cesarean deliveries. Pelvic pain and abnormal uterine bleeding are common complaints in our clinical practice, and isthmocele should be included in the differential diagnosis, especially in women who underwent previous cesarean sections.
Isthmocele is a growing pathology due to the increase in the number of cesarean deliveries. Pelvic pain and abnormal uterine bleeding are common complaints in our clinical practice, and isthmocele should be included in the differential diagnosis, especially in women who underwent previous cesarean sections.
The effective treatment of non-unions and critical-sized defects remains a challenge in the orthopedic field. From a tissue engineering perspective, this issue can be addressed through the application bioactive matrixes to support bone regeneration, such as Bonelike®, as opposed to the widespread autologous grafting technique. An improved formulation of Bonelike® Poro, was assessed as a synthetic bone substitut...
Background: India is a patchwork of tribal and non-tribal populations that speak many different languages from various language families. Indo-European, spoken across northern and central India, and also in Pakistan and Bangladesh, has been frequently connected to the so-called “Indo-Aryan invasions” from Central Asia ~3.5 ka and the establishment of the caste system, but the extent of immigration at this time ...
There are two very different interpretations of the prehistory of Island Southeast Asia (ISEA), with genetic evidence invoked in support of both. The "out-of-Taiwan" model proposes a major Late Holocene expansion of Neolithic Austronesian speakers from Taiwan. An alternative, proposing that Late Glacial/postglacial sea-level rises triggered largely autochthonous dispersals, accounts for some otherwise enigmatic...
There has been a long-standing debate concerning the extent to which the spread of Neolithic ceramics and Malay-Polynesian languages in Island Southeast Asia (ISEA) were coupled to an agriculturally driven demic dispersal out of Taiwan 4000 years ago (4 ka). We previously addressed this question using founder analysis of mitochondrial DNA (mtDNA) control-region sequences to identify major lineage clusters most ...
A high-resolution mtDNA phylogenetic tree allowed us to look backward in time to investigate purifying selection. Purifying selection was very strong in the last 2,500 years, continuously eliminating pathogenic mutations back until the end of the Younger Dryas (∼11,000 years ago), when a large population expansion likely relaxed selection pressure. This was preceded by a phase of stable selection until another ...
As fraturas da extremidade superior do fémur, nomeadamente as fraturas trocantéricas, continuam a representar um sério problema de saúde pública em idosos com osteoporose, presentando um elevado índice de morbilidade e mortalidade, apesar dos avanços registados tanto na sua prevenção como no seu tratamento. Apenas o tratamento cirúrgico pode permitir uma marcha e uma recuperação funcional precoces, por forma qu...