18 documents found, page 1 of 2
ABCB1 C1236T, G2677TA and C3435T genetic polymorphisms and antidepressant respo...
Santos, Marlene; Lima, Luís; Carvalho, Serafim; Brandão, Andreia; Barroso, Fátima; Cruz, Agostinho; Medeiros, RuiP-glycoprotein (P-GP) is a transporter molecule expressed on the apical surface of capillary endothelial cells of the Blood–Brain Barrier (BBB), whose activity heavily influences drug distribution, including antidepressants. This transporter is encoded by ABCB1 gene, and genetic variations within ABCB1 gene have been proposed to affect drug efflux and have been previously associated with depression. In this con...
A genetic chronology for the Indian Subcontinent points to heavily sex-biased d...
Silva, Marina; Oliveira, Marisa; Vieira, Daniel; Brandão, Andreia; Rito, Teresa S; Pereira, Joana B.; Fraser, Ross M.; Hudson, Bob; Gandini, FrancescaBackground: India is a patchwork of tribal and non-tribal populations that speak many different languages from various language families. Indo-European, spoken across northern and central India, and also in Pakistan and Bangladesh, has been frequently connected to the so-called "Indo-Aryan invasions" from Central Asia similar to 3.5 ka and the establishment of the caste system, but the extent of immigration at ...
A benchmarking analysis of open-source business intelligence tools in healthcar...
Brandão, Andreia; Pereira, Eliana; Esteves, Marisa; Portela, Carlos Filipe; Santos, Manuel Filipe; Abelha, António; Machado, JoséIn recent years, a wide range of Business Intelligence (BI) technologies have been applied to different areas in order to support the decision-making process. BI enables the extraction of knowledge from the data stored. The healthcare industry is no exception, and so BI applications have been under investigation across multiple units of different institutions. Thus, in this article, we intend to analyze some op...
A benchmarking analysis of open-source business intelligence tools in healthcar...
Brandão, Andreia; Pereira, Eliana Sofia Cunha; Esteves, Marisa Araújo; Portela, Filipe; Santos, Manuel Filipe; Abelha, António; Machado, José ManuelIn recent years, a wide range of Business Intelligence (BI) technologies have been applied to different areas in order to support the decision-making process. BI enables the extraction of knowledge from the data stored. The healthcare industry is no exception, and so BI applications have been under investigation across multiple units of different institutions. Thus, in this article, we intend to analyze some op...
Quantifying the legacy of the Chinese Neolithic on the maternal genetic heritag...
Brandão, Andreia; Eng, Ken Khong; Rito, Teresa S; Cavadas, Bruno; Bulbeck, David; Gandini, Francesca; Pala, Maria; Mormina, Maru; Hudson, BobThere has been a long-standing debate concerning the extent to which the spread of Neolithic ceramics and Malay-Polynesian languages in Island Southeast Asia (ISEA) were coupled to an agriculturally driven demic dispersal out of Taiwan 4000 years ago (4 ka). We previously addressed this question using founder analysis of mitochondrial DNA (mtDNA) control-region sequences to identify major lineage clusters most ...
Step towards to improve the voluntary interruption of pregnancy by means of bus...
Brandão, Andreia; Portela, FilipeWith the implementation of Information and Communication Technologies in the health sector, it became possible the existence of an electronic record of information for patients, enabling the storage and the availability of their information in databases. However, without the implementation of a Business Intelligence (BI) system, this information has no value. Thus, the major motivation of this paper is to creat...
Resolving the ancestry of Austronesian‑speaking populations
Soares, Pedro; Trejaut, Jean A.; Rito, Teresa S; Cavadas, Bruno; Hill, Catherine; Eng, Ken Khong; Mormina, Maru; Brandão, Andreia; Fraser, Ross M.There are two very different interpretations of the prehistory of Island Southeast Asia (ISEA), with genetic evidence invoked in support of both. The "out-of-Taiwan" model proposes a major Late Holocene expansion of Neolithic Austronesian speakers from Taiwan. An alternative, proposing that Late Glacial/postglacial sea-level rises triggered largely autochthonous dispersals, accounts for some otherwise enigmatic...
Fine time scaling of purifying selection on human nonsynonymous mtDNA mutations...
Cavadas, Bruno; Soares, Pedro; Camacho, Rui; Brandão, Andreia; Costa, Marta D; Fernandes, Verónica; Pereira, Joana B; Rito, Teresa S; Samuels, David CA high-resolution mtDNA phylogenetic tree allowed us to look backward in time to investigate purifying selection. Purifying selection was very strong in the last 2,500 years, continuously eliminating pathogenic mutations back until the end of the Younger Dryas (∼11,000 years ago), when a large population expansion likely relaxed selection pressure. This was preceded by a phase of stable selection until another ...
Improving quality of services in maternity care triage system
Abelha, António; Pereira, Eliana; Brandão, Andreia; Portela, Filipe; Santos, Manuel Filipe; Machado, José Manuel; Braga, JorgeThe main objectives in hospital triages are to improve the quality of care and reduce the risks associated to the waiting time in emergency care. Thus, an efficient triage is a good way to avoid some future problems and how much quicker it is, more the patient can benefit. The most common triage system is the Manchester Triage System (MTS). MTS is a reliable system focused in the hospital emergency department. ...
Predicting the risk associated to pregnancy using data mining
Machado, José Manuel; Abelha, António; Santos, Manuel; Portela, Filipe; Pereira, Eliana; Brandão, AndreiaWoman willing to terminate pregnancy should in general use a specialized health unit, as it is the case of Maternidade Júlio Dinis in Porto, Portugal. One of the four stages comprising the process is evaluation. The purpose of this article is to evaluate the process of Voluntary Termination of Pregnancy and, consequently, identify the risk associated to the patients. Data Mining (DM) models were induced to pred...