17 documents found, page 1 of 2
Prenylated flavonoid-enriched fraction from maclura tinctoria shows biological ...
Almeida, Ayla das Chagas; Rodrigues, Laís Azevedo; Paulino, Graziela dos Santos; Aguilar, Ananda Pereira; Almeida, Alisson AndradeBackground: The Atlantic Forest biome extends along the entire Brazilian coast and is home to approximately 20,000 plant species, many of which are endemic; it is considered one of the hotspot regions of the planet. Several of these species are sources of natural products with biological activities that are still unknown. In this study, we evaluated the antimicrobial activity of 90 extracts derived from native ...
Different source of commercial vegetable oils may regulate metabolic, inflammat...
Gomes, Sttefany Viana; Dias, Bruna Vidal; Pereira, Renata Rebeca; Lúcio, Karine de Pádua; Souza, Débora Maria Soares de; Silva, André Talvani Pedrosa daOur goal was to carry out a comparative study to evaluate the metabolic and inflammatory effects and the redox status of commercial vegetable oils supplementation [linseed (LO), coconut (VCO), and sunflower (SO)] in metabolically healthy rats. The results found in this study showed that the LO group decreased the HOMA-IR and hepatic cholesterol, and increased the serum levels of IL-6. Supplementation with VCO i...
Antioxidant study indicative of antibacterial and antimutagenic activities of a...
Diaz, Marisa Alves Nogueira; Fietto, Luciano Gomes; Leite, João Paulo Viana; Gontijo, Douglas Costa; Gontijo, Pablo Costa; Brandão, Geraldo CélioEthnopharmacological relevance; Several plant species of Miconia genus are commonly used in Brazilian folk medicine as anti-inflammatory agents and for the treatment of infectious diseases. Infusions and extracts of Miconia species are also reported as analgesic, antimicrobial, antimalarial, antioxidant, anti-inflammatory, antinociceptive, antimutagenic, and antitumoral. To determine the phytochemical compositi...
Anti-Inflammatory and antioxidant properties of black mulberry (Morus nigra L.)...
Lúcio, Karine de Pádua; Rabelo, Ana Carolina Silveira; Araújo, Carolina Morais; Brandão, Geraldo Célio; Souza, Gustavo Henrique Bianco deSepsis is a complex disease and is the cause of many deaths worldwide. Sepsis pathogenesis involves a dysregulated inflammatory response with consequent production of inflammatory mediators and reactive species. The production and excessive release of these substances into the systemic circulation trigger various cellular and metabolic alterations that are observed during the disease evolution. Thus, more studi...
Aqueous extract of Baccharis trimera improves redox status and decreases the se...
Rabelo, Ana Carolina Silveira; Araújo, Glaucy Rodrigues de; Lúcio, Karine de Pádua; Araújo, Carolina Morais; Miranda, Pedro Henrique de AmorimThe metabolism of ethanol occurs mainly in the liver, promoting increase of reactive oxygen species and nitrogen, leading to redox imbalance. Therefore, antioxidants can be seen as an alternative to reestablish the oxidizing/reducing equilibrium. The aim of this study was to evaluate the antioxidant and hepatoprotective effect of aqueous extract of Baccharis trimera (Less.) DC., Asteraceae, in a model of hepato...
Identification of phenolic compounds and biologically related activities from O...
Gontijo, Douglas Costa; Brandão, Geraldo Célio; Gontijo, Pablo Costa; Oliveira, Alaíde Braga de; Diaz, Marisa Alves Nogueira; Fietto, Luciano GomesOcotea odorifera (Vell.) Rohwer is popularly used as food and flavoring. The aim of this study was to determine the chemical composition of the aqueous extract from O. odorifera leaves and evaluate the correlation of their phytochemical composition and biological activities. The antioxidant effect was determined by DPPH radical scavenging, β-carotene-linoleic acid and lipid peroxidation assays; the antibacteria...
Antileishmanial Activity of Handroanthus serratifolius (Vahl) S. Grose (Bignoni...
Costa, Erica Vanessa Souza; Brígido, Heliton Patrick Cordovil; Silva, João Victor da Silva e; Coelho-Ferreira, Marlia Regina; Brandão, Geraldo CélioEste estudo teve como objetivo avaliar a atividade leishmanicida do extrato etanólico, frações e substância isolada de Handroanthus serratifolius contra Leishmania amazonensis. Além disso, essa atividade estava relacionada à citotoxicidade e o índice de seletividade O extrato etanólico foi obtido por maceração do pó do caule e o extrato foi submetido ao fracionamento em coluna cromatogrica. O lapachol foi obtid...
Identification of phenolic compounds and biologically related activities from O...
Gontijo, Douglas da Costa; Brandão, Geraldo Célio; Gontijo, Pablo Costa; Oliveira, Alaíde Braga de; Diaz, Marisa Alves Nogueira; Fietto, Luciano GomesOcotea odorifera (Vell.) Rohwer is popularly used as food and flavoring. The aim of this study was to determine the chemical composition of the aqueous extract from O. odorifera leaves and evaluate the correlation of their phytochemical composition and biological activities. The antioxidant effect was determined by DPPH radical scavenging, b-carotene-linoleic acid and lipid peroxidation assays; the antibacteria...
Antiviral activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) ...
Brandão, Geraldo Célio; Kroon, Erna Geessien; Souza Filho, José Dias de; Oliveira, Alaíde Braga deA phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WRwith best results for the fruits e...
Antileishmanial activity of Handroanthus serratifolius (Vahl) S. Grose (Bignoni...
Costa, Erica Vanessa Souza; Brígido, Heliton Patrick Cordovil; Silva, João Victor da Silva e; Ferreira, Marlia Regina Coelho; Brandão, Geraldo CélioThis study aimed to evaluate the leishmanicidal activity of ethanol extract, fractions, and isolated substance from Handroanthus serratifolius against Leishmania amazonensis. Furthermore, this activity was related to cytotoxicity, and the selectivity index was determined.The ethanol extract was obtained by maceration of the stem powder, and the extract was subjected to fractionation on chromatographic column. T...