2 documents found, page 1 of 1
Cumulus cell DNA damage linked to fertilization success in females with an ovul...
Rodrigues, Bárbara; Sousa, Vanessa; Esteves, Filipa; Vale-Fernandes, Emídio; Costa, Solange; Sousa, Daniela; Brandão, Raquel; Leal, Carla; Pires, JoanaIntracytoplasmic sperm injection (ICSI) is a widely used technique in fertility centers. ICSI success depends on both nuclear and cytoplasmic oocyte maturation. Cumulus cells, which surround the oocytes, play a pivotal role in oocyte competence. However, the significance of DNA damage in cumulus cells as a marker of fertilization success remains largely unexplored. This study aims to investigate the relationshi...
Cumulus cells damage can help to indirectly predict oocyte quality in infertile...
Rodrigues, Bárbara; Sousa, Vanessa; Esteves, Filipa; Pires, Joana; Sousa, Daniela; Brandão, Raquel; Leal, Carla; Santos, Rosário; Vale-Fernandes, EmídioIntroduction: Intracytoplasmic sperm injection (ICSI) is currently used in clinical practice for couples with fertility issues. Some studies have shown an association between male reproductive ability and sperm DNA damage levels, assessed by comet assay. However, little is known regarding this endpoint and female fertility, mostly due to tissue accessibility. To overcome this, we used cumulus cells (CC) to anal...