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Effect of TNF-alpha blockade in monocrotaline-induced pulmonary hypertension
Henriques-Coelho, T; Brandão-Nogueira, A; Moreira-Gonçalves, D; Correia-Pinto, J; Leite-Moreira, AFINTRODUCTION: TNF-alpha blockade in ischemic heart failure is still the subject of debate since clinical trials show conflicting results. However, its benefit in heart failure secondary to pulmonary hypertension has yet to be determined. It has been reported that transgenic rats overexpressing TNF-alpha develop pulmonary hypertension. The aim of this study was to assess the morphologic and hemodynamic effects o...
Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating inter...
Henriques-Coelho, T; Oliveira, SM; Moura, RS; Roncon-Albuquerque R, Jr.; Neves, AL; Santos, M; Nogueira-Silva, C; La Fuente Carvalho, FThe pathogenesis of pulmonary hypertension (PH) includes an inflammatory response. Thymulin, a zinc-dependent thymic hormone, has important immunobiological effects by inhibiting various proinflammatory cytokines and chemokines. We investigated morphological and hemodynamic effects of thymulin administration in a rat model of monocrotaline (MCT)-induced PH, as well as the pattern of proinflammatory cytokine gen...
Ghrelin reverses molecular, structural and hemodynamic alterations of the right...
Henriques-Coelho, T; Roncon-Albuquerque R, Jr.; Lourenço, AP; Baptista, MJ; Oliveira, SM; Brandão-Nogueira, A; Correia-Pinto, J; Leite-Moreira, AF
Activation profile of pro-inflammatory cytokines in acute cardiac overload
Roncon-Albuquerque R, Jr.; Vasconcelos, M; Lourenço, AP; Brandão-Nogueira, A; Teles, A; Faria, B; Henriques-Coelho, T; Leite-Moreira, AF
Endogenous production of ghrelin and beneficial effects of its exogenous admini...
Henriques-Coelho, T; Correia-Pinto, J; Roncon-Albuquerque R, Jr.; Baptista, MJ; Lourenço, AP; Oliveira, SM; Brandão-Nogueira, A; Teles, A; Fortunato, JMWe investigated the endogenous production of ghrelin as well as cardiac and pulmonary vascular effects of its administration in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH). Adult Wistar rats randomly received a subcutaneous injection of MCT (60 mg/kg) or an equal volume of vehicle. One week later, animals were randomly assigned to receive a subcutaneous injection of ghrelin (100 mug/k...