4 documents found, page 1 of 1
Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ul...
Fraga, Alexandra G.; Branquinho, Gabriela Alexandra Trigo; Murthy, Ramya K.; Akhtar, Shamim; Hebbur, Madhavi; Pacheco, Ana Rita; Dominguez, JuanBuruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans. Although the current antibiotic treatment for BU is effective, daily administrations for a prolonged period of time, combined with potential risk of severe side effects, negatively impact on patient adherence. In that sense, we tested the efficacy of an alternative strategy based on Lysin B (LysB), a phage encoded lipolytic enzyme...
Spontaneous healing of Mycobacterium ulcerans lesions in the guinea pig model
Gomes, Rita Silva; Marcq, Elly; Branquinho, Gabriela Alexandra Trigo; Gonçalves, Carine M.; Longatto Filho, Adhemar; Castro, António G.; Pedrosa, JorgeBuruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans infection. BU is characterized by a wide range of clinical forms, including non-ulcerative cutaneous lesions that can evolve into severe ulcers if left untreated. Nevertheless, spontaneous healing has been reported to occur, although knowledge on this process is scarce both in naturally infected humans and experimental models of in...
Experimental phage therapy against Mycobacterium ulcerans in mice model
Branquinho, Gabriela Alexandra Trigo; Martins, Teresa G.; Fraga, Alexandra G.; Azeredo, Joana; Castro, António G.; Pedrosa, Jorge
Estudos em Mastite induzida po Streptococcus agalactiae em Bovinos e num modelo...
Branquinho, Gabriela Alexandra Trigo