4 documents found, page 1 of 1
Optimizing magnetic hyperthermia for melanoma
Simões, Beatriz T.; Chaparro, Catarina; Vieira, Tânia; Valente, Manuel A.; Cavaco, Marco C. V.; Neves, Vera; Silva, Jorge C.; Borges, João PauloFunding Information: This work was financed by FCT—Portuguese Foundation for Science and Technology, in the framework of the project PTDC/BTM-MAT/2472/2021 and projects LA/P/0037/2020, UIDP/50025/2020 and UIDB/50025/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. C.I.P.C. is supported by the grant SFRH/BD/148588/2019 from the Portuguese Foundation for Science...
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic ...
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, NunoPublisher Copyright: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.; In Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB...
A Promising Approach
Chaparro, Catarina I. P.; Simões, Beatriz T.; Borges, João P.; Castanho, Miguel A. R. B.; Soares, Paula I. P.; Neves, VeraPublisher Copyright: © 2023 by the authors.; Among central nervous system (CNS) disorders, Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and a major cause of dementia worldwide. The yet unclear etiology of AD and the high impenetrability of the blood–brain barrier (BBB) limit most therapeutic compounds from reaching the brain. Although many efforts have been made to effectively deliv...
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced ...
Belo, Rita F.; Martins, Margarida L.F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, VeraKyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer’s disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, and recent data showed that intracerebroventricular (i.c.v.) injection of KTP ameliorates memor...