Stanozolol is a steroid that causes lipid deposition in LDLr-/- mice, although the mechanism by which this dyslipidemia results in cardiac dysfunction is little understood. The aim of this study was to evaluate the effect of stanozolol on cardiac contractility and the participation of myocardial phospholamban (pPLB) phosphorylation in an atherosclerosis mouse model. LDL receptor knockout mice (LDLr-/-) were fed...
O estudo objetivou avaliar o nível de conhecimento dos farmacêuticos sobre o Protocolo Clínico e Diretrizes Terapêuticas (PCDT)/Dislipidemia, antes e após treinamento, para implantação de serviços clínicos em farmácia pública de dispensação de medicamentos especializados e a percepção de usuários dislipidêmicos atendidos nesta farmácia, sobre o uso, as reações adversas e medidas de promoção da saúde, antes e ap...
Background: Juçara açaí is a Brazilian berry with high anthocyanidin content and high antioxidant properties. A correlation between oxidative stress, hypertension and baroreflex impairment is known, however, no previous studies investigate the effect of juçara fruit pulp on hypertension. Aim: The aim of this study was to investigate antihypertensive effect of juçara (Euterpe edulis) fruit pulp in SHR animals, i...
This study aimed to evaluate the knowledge of pharmacists about Metabolic Syndrome (MS) and Pharmaceutical Care before and after participating in a training process for the implementation of clinical pharmacy in community pharmacies and to understand the perception of pharmacists about the teaching-learning process. This is a descriptive observational study with a quali-quatitative approach carried out with pha...
Metabolism of anabolic androgenic steroids is important for its physiological effects. The aim was to investigate the effects of finasteride (a 5α-reductase inhibitor - 5αR) on cardiac and mutagenic effects promoted by ND. Male Wistar rats were separated into three groups: CONT, received the vehicles of ND and finasteride (Peanut oil+Saline); DECA group, received ND (20 mg.kg.week-1, i.m.), and DECAF received N...