5 documents found, page 1 of 1
Efeito antimicrobiano, antioxidante, anti-inflamatório e gastroprotetor de nitr...
Sasahara, Greyce LuriGastric lesions are related to multifactorial causes such as Helicobacter pylori infection, excessive consumption of non-steroidal anti-inflammatory drugs (NSAIDs), and ethanol. The inflammatory process and the production of reactive oxygen species (ROS) amplify tissue damage and hinder the healing process. Objective: To investigate the anti-inflammatory, antioxidant, antimicrobial, and gastroprotective effects...
Antioxidant and anti-inflammatory activities of Bauhinia ungulata L. (Fabaceae)...
Rodrigues, Raphael de Oliveira; Yaochite, Juliana Navarro Ueda; Braga, Milena Aguiar; Sousa, Amanda Ribeiro de; Sasahara, Greyce LuriObjective: The present study aimed to investigate the antioxidant, immunomodulatory and antimicrobial activities of Bauhinia ungulata L. Method: A flavonoid-rich fraction was obtained from the Bauhinia ungulata L stem, called the ethyl acetate fraction of Bauhinia ungulata (FABU). The total antioxidant capacity of the FABU was determined through the phosphomolibdenium reduction method. For the evaluation of its...
Association of IL10 , IL4 , IFNG , and CTLA4 gene polymorphisms with efavirenz ...
Rodrigues, Raphael de Oliveira; Rabenhorst, Silvia Helena Barem; Carvalho, Paulo Germano de; Sasahara, Greyce Luri; Vasconcelos, Luciana Mabel FerreiraSUMMARY: We evaluated interleukin-10 ( IL10 ) － 592 C / A, IL4 － 589 C / T, interferon gamma ( IFNG ) ＋ 874 A / T, cytotoxic T-lymphocyte-associated antigen 4 ( CTLA4 ) ＋ 49 A / G gene polymorphisms associated with efavirenz hypersensitivity reaction. A total of 63 human immunodeficiency virus-positive patients under treatment at a public hospital were included in the study, of whom 21 presented with efavirenz ...
Polymorphism of IL10, IL4, CTLA4, and DAO genes in cross-reactive nonsteroidal ...
Vasconcelos, Luciana Mabel Ferreira; Rodrigues, Raphael de Oliveira; Albuquerque, Andressa Almeida; Barroso, Gabrielle Dantheias; Sasahara, Greyce LuriOur aim was to evaluate genetic polymorphism of molecules involved in immunoregulatory/allergic processes in patients who presented with cutaneous hypersensitivity caused by chemically unrelated nonsteroidal anti-inflammatory drugs. Polymorphisms at IL10 (–1082 G>A), IL4 (–589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases and 97 controls by the polymerase chain reaction-restriction fr...
Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell ana...
Pedrosa, Alano Martins; Barbosa, Maritza Cavalcante; Santos, Thayna Nogueira dos; Leal, Luzia Kalyne Almeida Moreira; Lopes, Amanda de AraújoA hidroxiuréia (HU) constitui o avanço mais importante no tratamento da anemia falciforme (AF) por prevenir complicações e aumentar a qualidade de vida dos pacientes. Entretanto, alguns aspectos do tratamento com HU permanecem obscuros, incluindo a sua ação e potencial toxicidade em outras células sanguíneas, tais como neutrófilos. Este estudo utilizou a mensuração da lactato desidrogenase (LDH) e do metil tiaz...