19 documents found, page 1 of 2
Sudden and Transient Block of Left Brain Hemisphere Activity in Catatonic Patie...
Melo, António; Bravo, Joana; Silva dos Santos, Amílcar; Gusmão, Ricardo; Lara, ElsaIntroduction: In the last 21 years, there has been an increase in studies on visual and quantitative EEG (qEEG). Although new findings have been reported, such as the extreme delta brush waves in anti-NMDA receptors encephalitis, there are still undocumented visual EEG alterations. In Psychiatry, these new findings are harder to detect because most patients do not undergo routine EEG. In this work, we report fo...
Quantitative EEG (qEEG) in Patients with Bipolar Psychotic Depression and Unipo...
Bravo, Joana; Silva dos Santos, Amílcar; Melo, António; Sales, Miguel; Mendonça, Pedro; Nagornova, Zhanna; Beljakov, Grigory; Shemyakina, NataliaIn the last 21 years, there has been an increase in studies on quantitative electroencephalogram (qEEG) in psychiatry. Patients with unipolar and bipolar depression show different brain wave patterns. However, there is no consensus on the findings. In this study, we aimed to clarify some qEEG changes in patients with unipolar psychotic depression (UPD) and bipolar psychotic depression (BPD) during the ECT cours...
Uncovering the microglia response during neonatal Group B Streptococcus meningitis
Soares, Joana; Lorga, Inês; Bravo, Joana; Summavielle, Teresa; Nova, Manuel Vila; Bonifácio Andrade, ElvaGroup B Streptococcus (GBS) remains the most common bacterial cause of meningitis in neonates. Microglia, the brain resident immune cells, have a critical role in the development of neural circuits. However, the role of GBS infection on microglia activation and neurological sequelae remains poorly characterised. Here, we aimed to evaluate whether GBS induces changes in microglia profile during the acute phase o...
The impact of psychostimulants on central and peripheral neuro-immune regulatio...
Bravo, Joana; Magalhães, Catarina; Andrade, Elva B.; Magalhães, Ana; Summavielle, TeresaIt is now well-accepted that psychostimulants act on glial cells causing neuroinflammation and adding to the neurotoxic effects of such substances. Neuroinflammation can be described as an inflammatory response, within the CNS, mediated through several cytokines, reactive oxygen species, chemokines and other inflammatory markers. These inflammatory players, in particular cytokines, play important roles. Several...
Regulation of CD47 expression by interferon-gamma under chronic Methamphetamine...
Rodrigues, João; Bravo, Joana; Bonifácio Andrade, Elva; Canedo, Teresa; Azevedo, Maria; Summavielle, TeresaExposure to methamphetamine (Meth), a highly addictive widely used psychostimulant, is classically associated with damage to neuronal terminals, but its neurotoxicity can also be mediated via activation of the neuroinflammatory response. Microglia, the resident immune cells of the brain, become highly activated and increase the release of proinflammatory mediators upon exposure to Meth. However, their role in M...
Neuron–microglia contact-dependent mechanisms attenuate methamphetamine-induced...
Bravo, Joana; Ribeiro, Inês; Terceiro, Ana Filipa; Andrade, Elva B.; Portugal, Camila Cabral; Lopes, Igor M.; Azevedo, Maria M.; Sousa, MafaldaExposure to methamphetamine (Meth) has been classically associated with damage to neuronal terminals. However, it is now becoming clear that addiction may also result from the interplay between glial cells and neurons. Recently, we demonstrated that binge Meth administration promotes microgliosis and microglia pro-inflammation via astrocytic glutamate release in a TNF/IP3R2-Ca2+-dependent manner. Here, we inves...
Neuron-microglia contact-dependent mechanisms attenuate methamphetamine-induced...
Bravo, Joana; Ribeiro, Inês Moreira; Terceiro, Ana Filipa; Andrade, Elva B.; Portugal, Camila Cabral; Lopes, Igor M.; Azevedo, Maria M.; Sousa, MafaldaExposure to methamphetamine (Meth) has been classically associated with damage to neuronal terminals. However, it is now becoming clear that addiction may also result from the interplay between glial cells and neurons. Recently, we demonstrated that binge Meth administration promotes microgliosis and microglia pro-inflammation via astrocytic glutamate release in a TNF/IP<sub>3</sub>R2-Ca<sup>2+</sup>-dependent ...
Astrocyte-derived TNF and glutamate critically modulate microglia activation by...
Canedo, Teresa; Portugal, Camila Cabral; Socodato, Renato; Almeida, Tiago Oliveira; Terceiro, Ana Filipa; Bravo, Joana; Silva, Ana IsabelMethamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational purposes. Besides disrupting the monoaminergic system and promoting oxidative brain damage, Meth also causes neuroinflammation, contributing to synaptic dysfunction and behavioral deficits. Aberrant activation of microglia, the largest myeloid cell population in the brain, is a common feature in neurological disorders tri...
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signal...
Brás, João Paulo; Bravo, Joana; Freitas, Jaime; Barbosa, Mário Adolfo; Santos, Susana Gomes; Summavielle, TeresaGrowing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders. In some pathological conditions, microglia produce increased levels of cytotoxic and inflammatory mediators, such as tumor necrosis factor alpha (TNF-α), which can reactivate microglia in a positive feedback mechanism....
Repeated exposure to ketamine in adolescent rats results in persistent anxiety ...
Amorim, Manuela; Bravo, Joana; Silva, Ana Isabel; Alves, Cecília Juliana; Monteiro, Pedro; Magalhãess, Ana; Summavielle, TeresaAdolescent development of the prefrontal cortex (PFC) is accompanied by important changes in glutamatergic, GABAergic and dopaminergic circuitries, susceptible to modulation by N-methyl-D-aspartate receptors (NMDAR) antagonists. Repeated ketamine was associated with social and memory deficits, but other relevant factors, such as anxiety, were not sufficiently addressed. The present study aimed to examine the be...