116 documents found, page 1 of 12
Anti-Inflammatory Meroterpenoids of Cordia glazioviana (Boraginaceae)
Silva,Ana Karine O.; Pinto,Francisco C. L.; Canuto,Kirley M.; Braz-Filho,Raimundo; Silva,Rose Anny C.; Santos,Flávia A.; Monteiro,Norberto K. V.The phytochemical reinvestigation from the heartwood of the extracts of Cordia glazioviana led to the isolation of four still undescribed hydroquinones derivatives designated as cordiaquinol D (1), cordiaquinol E (2), (10R)-10,11-dihydrofuran-1,4-dihydroxy-globiferin (3) and 2-[(1’E,6’E)-3’,8’- dihydroxy-3’,7’-dimethylocta-1’,6’-dienyl]-benzene-1,4-diol (4), along with the naphthoquinone 6-[(2’R)-2’-hydroxy-3’,...
DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sa...
Sales,Kaio A.; Pinheiro,Anderson A. V.; Araújo,Diego I. A. F.; Andrade,Rodrigo S. de; Agra,Maria de Fátima; Sobral,Marianna V.; Magalhães,Hemerson I. F.A chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsam...
Terpenoids isolated from Azadirachta indica roots and biological activities
Passos,Michel de S.; Carvalho Junior,Almir R. de; Boeno,Samyra I.; Virgens,Lorena de L. Glória das; Calixto,Sanderson Dias; Ventura,Thatiana Lopes BiáAbstract The chemical study of roots from Azadirachta indica A. Juss., Meliaceae, led to the isolation of two new terpenoids, limonoid morenolide and diterpene 17-hydroxy-sandaracopimar-8,15-dien-11-one, in addition to the four well-known limonoids nimbinene, nimbinal, nimbandiol and salannin, and three diterpenoids nimbidiol, ferruginol, and 6,7-dehydroferruginol. Their structural elucidations were based on on...
New flavone and other compounds from Tephrosia egregia: assessing the cytotoxic...
Teixeira,Maria V.S.; Lima,Jefferson Q.; Pimenta,Antônia T.A.; Silva,Francisca R.L. da; Oliveira,Maria da Conceição F. de; Pereira,Italo G.ABSTRACT The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided a new flavone, 5-hydroxy-8-(1",2"-epoxy-3"-hydroxy-3"-methylbutyl)-7-methoxyflavone (1), in addition to eleven known compounds: pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecansone A, 2',6'-dimethoxy-4',5'-(2",2"-dimethyl)-pyranochalcone, pongachalcone, maackiain, β-sistosterol and i...
PHYTOCHEMISTRY INVESTIGATION OF CASEARIA ARBOREA (RICH.) URB. (SALICACEAE) AND ...
Leite-Ferreira,Maria D.; Rocha-Souza,Maria S.; Ramirez,Raphael R. de A.; Chaves,Otemberg S.; Teles,Yanna C. F.; Pereira,Fillipe de O.A phytochemical investigation from aerial parts of Casearia arborea (Rich.) Urb. (Salicaceae) led to isolation and identification of: sitosterol, 4-en-stigmast-3-one, 13-hydroxy-trans-ent-cleroda-3,14-diene,3-hydroxy-2-oxo-trans-ent-cleroda-3,14-diene (kolavelone), a mixture of 13-hydroxy-trans-ent-cleroda-3,14-diene and an ester ethyl hexadecanoate, kaempferol-3-O-a-L-arabinofuranoside and 4',5,7-trihydroxy-3'...
LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
Duarte,Susyanne L. F.; Nascimento,Yuri M.; Madeiro,Sara A. L.; Costa,Vicente C. O.; Agra,Maria F.; Sobral,Marianna V.; Braz-Filho,RaimundoThe secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalene-typelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic acti...
Phytochemical study of Pilosocereus pachycladus and antibiotic-resistance modif...
Brito-Filho,Severino Gonçalves de; Maciel,Jéssica Karina da Silva; Teles,Yanna Carolina Ferreira; Fernandes,Milen Maria Magalhães de SouzaABSTRACT Pilosocereus pachycladus F. Ritter, Cactaceae, popularly known as "facheiro", is used as food and traditional medicine in Brazilian caatinga ecoregion. The plant is used to treat prostate inflammation and urinary infection. The present work reports the first secondary metabolites isolated from P. pachycladus. Therefore, the isolated compound 4-hydroxy-3,5-dimethoxy benzaldehyde (syringaldehyde) was eva...
Chemical constituents from Bauhinia acuruana and their cytotoxicity
Góis,Roberto W.S.; Sousa,Leôncio M. de; Silva,Horlando C. da; Silva,Francisco E.F. da; Pimenta,Antonia T.A.; Lima,Mary A.S.; Arriaga,Angela M.C.ABSTRACT Phytochemical investigation of Bauhinia acuruana Moric., Fabaceae, resulted in the isolation of sixteen constituents, including two new compounds 2'-hydroxy-2,3,5-trimethoxybibenzyl (1), (2R,3S)-2-(3,4'-dihydroxyphenyl)-5-methoxy-6-methylchroman-3,7-diol (2), together with fourteen known ones (3–16). The structures of the compounds were established by spectroscopic analysis including HR-ESI-MS, 1D and ...
Angelocunhol: New Erythroxylane Diterpene and Other Compounds from Simira sampa...
Moreira,Vinicius F.; Vieira,Ivo J. C.; Braz-Filho,RaimundoThe first Simira sampaioana (Rubiaceae) phytochemical study allowed the isolation and structural determination of a new erythroxylane diterpene named Angelocunhol, 11β,12α-dihydroxy-2,4(18),15-eritroxilatrien-1-one, together with 14 known compounds: simirane B, harman, maxonine, isomalindine, malindine, sitost-4-en-6-ol-3-one, estigmast-4,22-dien-6-ol-3-one, campest-4-en-6-ol-3-one, sitost-4-en-3-one, stigmast-...
Studies of the Interaction between BSA and a Plumeran Indole Alkaloid Isolated ...
Chaves,Otávio A.; Teixeira,Flávia S. M.; Guimarães,Heloisa A.; Braz-Filho,Raimundo; Vieira,Ivo José C.; Sant'Anna,Carlos Mauricio R.Binding between bovine serum albumin (BSA) and a plumeran indole alkaloid (PIA) isolated from the stem bark of Aspidosperma cylindrocarpon (Apocynaceae) was studied by spectroscopic techniques (UV-Vis absorption, circular dichroism, steady state and time-resolved fluorescence), combined with molecular docking. Steady state and time resolved fluorescence data revealed that PIA can quench the BSA fluorescence via...