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Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidan...

Chavarria, Daniel; Da Silva, Ophelie; Benfeito, Sofia; Barreiro, Sandra; Garrido, Jorge; Cagide, Fernando; Soares, Pedro; Remião, Fernando

Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study aims to evaluate whether the π-system extension on the chemical scaffolds of AntiOXCIN2 and AntiOXCIN3 affects their bioactivity and safety profiles. After the syn...

Date: 2021   |   Origin: Estudo Geral - Universidade de Coimbra
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