5 documents found, page 1 of 1
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Diso...
Mullins, Niamh; Kang, JooEun; Campos, Adrian I; Coleman, Jonathan R I; Edwards, Alexis C; Galfalvy, Hanga; Levey, Daniel F; Lori, AdrianaBackground: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) c...
Analysis of shared heritability in common disorders of the brain
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, ValentinaDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...
Genome-wide association analyses identify new risk variants and the genetic arc...
van Rheenen, Wouter; Shatunov, Aleksey; Dekker, Annelot M.; McLaughlin, Russell L.; Diekstra, Frank P.; Pulit, Sara L.; van der Spek, Rick A. A.To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALS and matched controls (n = 1,861). Through imputation and mixed-model association analysis in 12,577 cases and 23,475 controls, combined with 2,579 cases and 2,767 controls in an independent replication cohort, we fin...
The posttraumatic stress disorder project in Brazil: neuropsychological, struct...
Bressan, Rodrigo Affonseca; Quarantini, Lucas de Castro; Andreoli, Sérgio Baxter; Araújo, Celia; Breen, Gerome; Guindalini, Camilap. 1-12; Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-08T15:58:47Z No. of bitstreams: 1 1471-244X-9-30.pdf: 499302 bytes, checksum: afa950222d367d53b0608150b904f1cc (MD5); Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T18:09:49Z (GMT) No. of bitstreams: 1 1471-244X-9-30.pdf: 499302 bytes, checksum: afa950222d367d53b0608150b904f1cc (MD5); Made available in ...
Dopamine-beta hydroxylase polymorphism and cocaine addiction
Breen, Gerome