77 documents found, page 1 of 8
Phylogeography of sub-Saharan mitochondrial lineages outside Africa highlights ...
Sá, Luísa; Almeida, Mafalda; Azonbakin, Simon; Matos, Erica; Franco-Duarte, Ricardo; Gómez-Carballa, Alberto; Salas, Antonio; Laleye, AnatóleDespite the importance of ancient DNA for understanding human prehistoric dispersals, poor survival means that data remain sparse for many areas in the tropics, including in Africa. In such instances, analysis of contemporary genomes remains invaluable. One promising approach is founder analysis, which identifies and dates migration events in non-recombining systems. However, it has yet to be fully exploited as...
Biomolecular insights into North African-related ancestry, mobility and diet in...
Silva, Marina; Oteo-García, Gonzalo; Martiniano, Rui; Guimarães, João; von Tersch, Matthew; Madour, Ali; Shoeib, Tarek; Fichera, AlessandroHistorical records document medieval immigration from North Africa to Iberia to create Islamic al-Andalus. Here, we present a low-coverage genome of an eleventh century CE man buried in an Islamic necropolis in Segorbe, near Valencia, Spain. Uniparental lineages indicate North African ancestry, but at the autosomal level he displays a mosaic of North African and European-like ancestries, distinct from any prese...
The Plundering of Funchal in 1566 and its Repercussions in the Reign of King Se...
Brehm, António; Trindade, CristinaIn 1566 a terrible event occurred in Madeira, with a raid by a band of pirates captained by the French Peyrot de Monluc. It is perhaps the only significant event related to piracy in the archipelago which was, moreover, well known by some of the most famous pirates and corsairs, Berbers or Europeans. Although Monluc died in the onslaught, his companions made a general plunder in Funchal, and then set sail unsca...
Colonization routes, microevolutionary genetic structure and conservation conce...
Moura, Mónica; Catalán, Pilar; Brehm, António; Sequeira, Miguel Menezes dePopulation genetic structure and diversity and phylogeographical dispersal routes were assessed for the Azorean endemic grass Deschampsia foliosa using AFLP markers. This species occurs on seven islands in the archipelago and a sampling of populations from the three main geographical groups of islands was used, covering its known distribution. Principal coordinates analyses (PCoAs), Bayesian analyses and phylog...
Polimorfismos Genéticos Associados ao Aparecimento de Hipertensão Arterial Numa...
Sousa, Ana Célia; Palma dos Reis, Roberto; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Gouveia, Sara; Góis, TeresaIntrodução: A hipertensão arterial é uma doença complexa, multifatorial, controlada por fatores genéticos e ambientais. Objetivo: Avaliar a susceptibilidade genética no aparecimento de hipertensão arterial e sua associação com os fatores de risco tradicionais na eclosão desta patologia. Material e Métodos: Estudo caso-controlo com 1712 indivíduos, idade média de 51,0 ± 7,9 anos (860 hipertensos e 852 controlos)...
Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in...
Pereira, Andreia; Mendonça, Maria Isabel; Borges, Sofia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana; Freitas, Ana Isabel; Sousa, Ana CéliaBackground: Genetic risk score can quantify individual’s predisposition to coronary artery disease; however, its usefulness as an independent risk predictor remains inconclusive. Objective: To evaluate the incremental predictive value of a genetic risk score to traditional risk factors associated with coronary disease. Methods: Thirty-three genetic variants previously associated with coronary disease were analy...
A variante genética c825t da subunidade β3 da proteína G associa‐se com a hiper...
Sousa, Ana Célia; Palma dos Reis, Roberto; Pereira, Andreia; Borges, Sofia; Gouveia, Sara; Spínola, Adelaide; Freitas, Ana Isabel; Guerra, GraçaHypertension is an important public health problem, affecting about 25% of the adult population worldwide.1 Genetic and environmental factors contribute to its pathogenesis. The T allele of the C825T polymorphism of the beta 3 subunit of G protein (rs5443) leads to the production of a truncated variant that enhances intracellular signaling and may interfere with the regulation of blood pressure. This genetic va...
Additional value of a combined genetic risk score to standard cardiovascular st...
Pereira, Andreia; Mendonca, Maria Isabel; Borges, Sofia; Sousa, Ana Célia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana; Freitas, Ana IsabelThe utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction. A total of 2888 individuals (1566 coronary patients and 1322 controls) were divided into three subgroups according to FRS. Multiplicative GRS was determined for 32 genetic varia...
Genetic Polymorphisms Associated with the Onset of Arterial Hypertension in a P...
Sousa, Ana Célia; Reis, Roberto Palma dos; Pereira, Andreia; Borges, Sofia; Freitas, Ana Isabel; Guerra, Graça; Gouveia, Sara; Góis, TeresaIntroduction: Arterial hypertension is a complex, multifactorial disease, controlled by genetic and environmental factors.Objective: Evaluate the genetic susceptibility for developing arterial hypertension and its association with the traditional risk factors in the outbreak of this pathology.Material and Methods: Case-control study with 1712 individuals, mean age of 51.0 ± 7.9 years (860 hypertensive patients ...
Review of the leaf-litter skinks (Scincidae: Panaspis) from the Gulf of Guinea ...
Soares, Leonor B.; Ceríaco, Luis M. P.; Marques, Mariana P.; Bastos-Silveira, Cristiane; Scheinberg, Lauren A.; Harris, D. James; Brehm, AntónioLeaf-litter skinks of the genus Panaspis are currently represented in the oceanic islands of the Gulf of Guinea by two species, Panaspis africana and P. annobonensis. Here we describe a third species, Panaspis thomensis sp. nov., endemic to São Tomé Island. Data from previous studies and a new phylogenetic analysis using the mitochondrial 16S gene shows that the new species is genetically divergent and reciproc...