2 documents found, page 1 of 1
Genotyping of Mycobacterium leprae for better understanding of leprosy transmis...
Fontes, Amanda N. B.; Lima, Luana N. G. C.; Mota, Rosa M. S.; Almeida, Rosa Lívia Freitas de; Pontes, Maria A.; Gonçalves, Heitor de S.Leprosy is endemic in large part of Brazil with 28,761 new patients in 2015, the second largest number worldwide and reaches 9/10.000 in highly endemic regions and 2.7/10.000 in the city of Fortaleza, Ceará, Northeast Brazil. For better understanding of risk factors for leprosy transmission, we conducted an epidemiologic study supplemented by 17 locus VNTR and SNP 1–4 typing of Mycobacterium leprae in skin biop...
Pathogen-specific epitopes as epidemiological tools for defining the magnitude ...
Martins, Marcia V. S. B.; Guimarães, Marjorie M. da S.; Spencer, John S.; Hacker, Mariana A. V. B.; Costa, Luciana S.; Carvalho, Fernanda M.During recent years, comparative genomic analysis has allowed the identification of Mycobacterium leprae -specific genes with potential application for the diagnosis of leprosy. In a previous study, 58 synthetic peptides derived from these sequences were tested for their ability to induce production of IFN- c in PBMC from endemic controls (EC) with unknown exposure to M. leprae , household contacts of leprosy p...