5 documents found, page 1 of 1
A Withanolide-rich Fraction of Athenaea velutina Induces Apoptosis and Cell Cyc...
Almeida, Alisson A.; Lima, Graziela D. A.; Eiterer, Marinês; Rodrigues, Laís A.; A. Do Vale, Juliana; Zanatta, Ana C. [UNESP]; Bressan, Gustavo C.Made available in DSpace on 2021-06-25T10:28:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Athenaea velutina is a promising Brazilian shrub with cytotoxic and antimigratory properties against cancer cells. However, the mechanism of induction of cancer cell death and the compounds involved remain unknown. To ascertain these bioactive compounds, bioassay-guided fractionation was performed, alon...
Screening of plants from the Brazilian Atlantic Forest led to the identificatio...
Almeida, Alisson A.; Lima, Graziela D. A.; Simão, Marcos V. R. C.; Moreira, Gabriela A.; Siqueira, Raoni P.; Zanatta, Ana C. [UNESP]Made available in DSpace on 2020-12-12T02:42:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01; Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Plant biodiversity is a source of potential natural products for the treatment of many diseases. One of the ways of discovering new drugs is through the cytotoxic scre...
A porcine circovirus-2 mutant isolated in Brazil contains low-frequency substit...
Salgado, Rafael Locatelli; Vidigal, Pedro Marcus Pereira; Gonzaga, Natalia F.; Souza, Luiz F. L. de; Polêto, Marcelo D.; Onofre, Thiago SouzaPorcine circovirus-2 (PCV2) is the etiologic agent of several diseases in pigs, including multi-systemic wasting syndrome (PMWS). In this work, a new mutant PCV2b was isolated from PMWS-affected pigs on a Brazilian farm. Its genome showed high sequence similarity (>99 % identity) to those from a group of emerging mutants isolated from cases of PMWS outbreaks in vaccinated pigs in China, the USA and South Korea....
Ki-1/57 and CGI-55 ectopic expression impact cellular pathways involved in prol...
Vidigal, Pedro M.; Costa, Fernanda C.; Saito, Ângela; Gonçalves, Kaliandra A.; Meirelles, Gabriela V.; Bressan, Gustavo C.; Kobarg, JörgKi-1/57 (HABP4) and CGI-55 (SERBP1) are regulatory proteins and paralogs with 40.7% amino acid sequence identity and 67.4% similarity. Functionally, they have been implicated in the regulation of gene expression on both the transcriptional and mRNA metabolism levels. A link with tumorigenesis is suggested, since both paralogs show altered expression levels in tumor cells and the Ki-1/57 gene is found in a regio...
Identification of an emergent porcine circovirus-2 in vaccinated pigs from a br...
Salgado, Rafael L.; Vidigal, Pedro M. P.; Souza, Luiz F. L. de; Onofre, Thiago S.; Gonzaga, Natália F.; Eller, Monique R.; Bressan, Gustavo C.Three porcine circovirus-2 strains were isolated from pigs on a Brazilian farm during an outbreak, indicating a vaccine failure. They present identical genomic sequences, with high identities to other isolates that were also related to vaccination failures, supporting the recent theory about an antigen drift being associated with vaccine failures throughout the world.