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Hierarchical design of fibrous tissue-mimetic scaffolds

Pardo, Alberto; Gómez-Florit, Manuel; Davidson, Matthew D; Öztürk-Öncel, M. Özgen; Domingues, Rui Miguel Andrade; Burdick, Jason A..; Gomes, Manuela E.

Most tissues of the human body present hierarchical fibrillar extracellular matrices that have a strong influence over their physicochemical properties and biological behavior. Of great interest is the introduction of this fibrillar structure to hydrogels, particularly due to the water-rich composition, cytocompatibility and tunable properties of this class of biomaterials. Here, the main bottom-up fabrication ...


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