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Dormant phages of Helicobacter pylori reveal distinct populations in Europe

Vale, F.F; Vadivelu, J.R.; Oleastro, Mónica; Breurec, S.; Engstrand, L.; Perets, T.T.; Mégraud, F.; Lehours, P.

Prophages of Helicobacter pylori, a bacterium known to co-evolve in the stomach of its human host, were recently identified. However, their role in the diversity of H. pylori strains is unknown. We demonstrate here and for the first time that the diversity of the prophage genes offers the ability to distinguish between European populations, and that H. pylori prophages and their host bacteria share a complex ev...


Screening of Prophage Sequences Among Helicobacter Pylori

Timóteo, Andreia; Breurec, S.; Oleastro, Mónica; Roxo-Rosa, Mónica; Vítor, Jorge; Lehours, Phillipe; Vale, Filipa

Until recently, Helicobacter pylori was considered a bacterium without prophages. The presence of an incomplete prophage sequence in strain B38 and a complete prophage sequence in strain B45 showed otherwise. Using a PCR strategy, based on degenerated primers designed after aligning bacteriophage integrase genes from H. pylori strains B38 and B45, and H. acinonychis prophage II, we found that integrase sequence...


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