4 documents found, page 1 of 1
The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity...
Gouveia, M; Brindley, P; Azevedo, C; Gärtner, F; Costa, JMC; Vale, NBackground: Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel (PZQ) for more than a generation. Despite its celebrated performance for treatment and control of schistosomiasis and other platyhelminth infections, praziquantel has some shortcomings and the inability of this drug to counteract disease sequelae prompts the need for novel therapeutic strategies. Methods: Using a host-para...
Combination anthelmintic/antioxidant activity against schistosoma mansoni
Gouveia, M; Brindley, P; Rinaldi, G; Gärtner, F; Costa, J; Vale, NSchistosomiasis is a major neglected tropical disease. Treatment for schistosomiasis with praziquantel (PZQ), which is effective against the parasite, by itself is not capable to counteract infection-associated disease lesions including hepatic fibrosis. There is a pressing need for novel therapies. Due to their biological properties, antioxidant biomolecules might be useful in treating and reverting associated...
Infection with carcinogenic helminth parasites and its production of metabolite...
Gouveia, M; Brindley, P; Rinaldi, G; Gärtner, F; Costa, J; Vale, NBackground: Infections classified as group 1 biological carcinogens include the helminthiases caused by Schistosoma haematobium and Opisthorchis viverrini. The molecular mediators underlying the infection with these parasites and cancer remain unclear. Although carcinogenesis is a multistep process, we have postulated that these parasites release metabolites including oxysterols and estrogen-like metabolites th...
Drug repurposing for schistosomiasis: Combinations of drugs or biomolecules
Gouveia, M; Brindley, P; Gärtner, F; Correia Da Costa, J; Vale, NSchistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently relies on a single drug, praziquantel, and despite its efficacy against the all schistosome species that parasitize humans, it displays some problematic drawbacks and alone is ineffective in counteracting adverse pathologies associated with infection. Moreover, due to the development of the potential emergence of PZQ-res...