10 documents found, page 1 of 1
Seasonal Storage for Space Heating using Solar DHW Surplus
Brites, Gonçalo; Garruço, Manuel; Fernandes, Marco S.; Pinto, Diogo M. Sá; Gaspar, Adélio RodriguesDue to the seasonality of solar energy, achieving 100 % of annual solar fraction for domestic hot water (DHW) production is only possible by greatly oversizing the collector area of a solar system, thus creating a significant energy surplus in summer. This simulation study investigates the possibility of using this surplus to promote space heating during winter, in a moderate South European climate, to try achi...
A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitiz...
Jesus, Ana; Sebastião, Ana I.; Brites, Gonçalo; Correia-da-Silva, Marta; Cidade, Honorina; Cruz, Maria T.; Sousa, Emília; Almeida, Isabel F.Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs its own incorporation into cosmetic formulations. RSV-GS is a synthetic hydrophilic sulfated glycosylated derivative inspired by marine natural products that present a lower cytotoxicity than RSV while exhibiting similar levels of bioactivity. Herein, we predict the skin sensitization potenti...
Development of an in chemico high-throughput screening method for the identific...
Ferreira, Isabel; Brites, Gonçalo; Silva, Ana; Caramelo, Francisco; Oliveiros, Bárbara; Neves, Bruno Miguel; Cruz, Maria TeresaIt is well established that chemical-peptide conjugation represents the molecular initiating event (MIE) in skin sensitization. This MIE has been successfully exploited in the development of in chemico peptide reactivity assays, with the Direct Peptide Reactivity Assay (DPRA) being validated as a screening tool for skin sensitization hazard as well as an OECD test guideline. This test relies on the use of a hig...
Exploring the antioxidant, anti-inflammatory and antiallergic potential of Braz...
Conte, Fernanda Lopes; Pereira, Ana Catarina; Brites, Gonçalo; Ferreira, Isabel; Silva, Ana Cristina; Sebastião, Ana Isabel; Matos, PatríciaPropolis is a bee product used since ancient times due to its diverse biological applications. We aimed to investigate the antioxidant and anti-inflammatory action of Brazilian propolis in THP-1 cells stimulated with 1‐fluoro‐2,4‐dinitrobenzene (DNFB) or lipopolysaccharide (LPS). Methods: Cell viability was assessed by resazurin assay, antioxidant activity was evaluated by DPPH assay, superoxide dismutase (SOD)...
Exploring the antioxidant, anti-inflammatory and antiallergic potential of Braz...
Conte, Fernanda Lopes [UNESP]; Pereira, Ana Catarina; Brites, Gonçalo; Ferreira, Isabel; Silva, Ana Cristina; Sebastião, Ana Isabel; Matos, PatríciaMade available in DSpace on 2022-05-01T15:13:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-05-01; Background: Propolis is a bee product used since ancient times due to its diverse biological applications. We aimed to investigate the antioxidant and anti-inflammatory action of Brazilian propolis in THP-1 cells stimulated with 1‐fluoro‐2,4‐dinitrobenzene (DNFB) or lipopolysaccharide (LPS). Methods: Ce...
Development of a new hydrogel for the prevention of allergic contact dermatitis
Brites, Gonçalo; Basso, João; Miranda, Margarida; Miguel Neves, Bruno; Vitorino, Carla; Cruz, Maria T.Allergic contact dermatitis (ACD) is the most prevalent occupational disease and the most common form of immunotoxicity in humans. Preventing exposure to the triggering allergens is the mainstay of treatment. However, avoidance is not always possible in an occupational setting. From a pathophysiological point of view, a variety of events are involved in the development of ACD, including the formation of immunog...
Open-Air Cold Plasma Device Leads to Selective Tumor Cell Cytotoxicity
Almeida-Ferreira, Catarina; Silva-Teixeira, Rafael; Laranjo, Mafalda; Almeida, Nuno; Brites, Gonçalo; Dias-Ferreira, João; Marques, Inês A.; Neves, RitaThe need for effective and safe therapies for cancer is growing as aging is modifying its epidemiology. Cold atmospheric plasma (CAP) has gained attention as a potential anti-tumor therapy. CAP is a gas with enough energy to ionize a significant fraction of its constituent particles, forming equal numbers of positive ions and electrons. Timely-resolved output voltage measurement, emission spectroscopy, and quan...
Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumo...
Laranjo, Mafalda; Aguiar, Márcia Campos; Pereira, Nelson A. M.; Brites, Gonçalo; Nascimento, Bruno F. O.; Brito, Ana F.; Casalta-Lopes, JoãoThe discovery of Pt-chlorin-type theranostic agents is described. Luminescent Pt(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, with different degrees of hydrophilicity, have been synthesized and their in vitro photocytotoxicity against human melanoma, oesophageal and bladder carcinomas was studied. A di(hydroxymethyl)-substituted chlorin was identified as a privileged molecule to explore imaging...
Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens...
Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; Silva, Maria ManuelExperimental evidence highlights nuclear factor (erythroid-derived 2)-like 2 (Nrf2) as a molecular target in Alzheimer's disease (AD). The well-known effect of electrophilic cysteine-reactive skin allergens on Nrf2-activation led to the hypothesis that these compounds could have a therapeutic role in AD. This was further supported by the neuroprotective activity of the skin allergen dimethyl fumarate (DMF), dem...
NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify
Sebastião, Ana Isabel; Ferreira, Isabel; Brites, Gonçalo; Silva, Ana; Neves, Bruno Miguel; Cruz, Maria TeresaAllergic contact dermatitis is a common occupational disease that manifests as a cell-mediated hypersensitivity reaction following skin exposure to small reactive chemicals termed haptens. Haptens penetrate the stratum corneum and covalently modify proteins in the epidermis, inducing intracellular stress, which further leads to the release of damage-associated molecular patterns (DAMPs), such as uric acid, reac...