13 documents found, page 1 of 2
Purpura Fulminans in a 20-Year-Old Female
Alves, Francisca; Brites, Maria Manuel; Coutinho, InêsA previously healthy 20-year-old female presented with extensive retiform purpura located at the face, upper and lower limbs, one week after an episode of acute tonsillitis. Despite the exuberance of the cutaneous findings and progression to skin necrosis she had no accompanying symptoms. Laboratory investigation revealed a heterozygous protein C mutation (exon 9, c.1332G> C, p.Trp444Cys), accounting for a p...
A Review of Acute Bacterial Dermo-hypodermatitis: Diabetes Mellitus Does Not In...
Batista, Mariana; Relvas, Maria; Calado, Rebeca; Brites, Maria Manuel; Gonçalo, MargaridaIntroduction: Acute bacterial dermo-hypodermatitis (DHAB) is an acute infection of the dermis and hypodermis that most often affects the lower limbs. Although diabetes mellitus has been identified as a risk factor for its development, recent studies have questioned this relationship. The aim of the present study was to compare clinical characteristics of inpatients with DHAB associated or not with diabetes mell...
Psoriasis, Psychotropic Drugs and Psychiatric Comorbidities: A Case-Control Stu...
Roque Ferreira, Bárbara; Santiago, Luís; Simões, João; Ramos, Leonor; Brites, Maria Manuel; Reis, José Pedro; Figueiredo, AméricoIntroduction: Psoriasis is a chronic inflammatory dermatosis with significant impact on quality of life and multiple comorbidities, with recognition especially given to cardiovascular risk factors. Recently it has been highlighted the high prevalence of psychiatric comorbidities.Methods: The primary outcome was to assess the prevalence of psychotropic drugs in the chronic medication of patients with diagnosis o...
A Case of Exuberant Elephantiasis Nostras Verrucosa
Santiago, Luís; Coutinho, Inês; Brites, Maria ManuelN/A.; N/A.
Vismodegib for Advanced Basal Cell Carcinoma Treatment – Experience of 3 Cases
Gameiro, Ana; Gouveia, Miguel; Brinca, Ana; Brites, Maria Manuel; Vieira, Ricardo; Figueiredo, AméricoBasal cell carcinoma represents the most common skin cancer and its incidence is increasing. Basal cell carcinoma is usually treated surgically or, as an alternative in selected cases, radiation therapy can be used either with curative or adjuvant intention. The designation “advanced basal cell carcinoma” is reserved for cases that cannot be treated by surgery and/or radiotherapy, or when these therapies would ...
Sirolimus and Primary Prevention of Non-melanoma Skin Cancer in Kidney Transpla...
Pinho, André; Aguiar, Brigite; Brites, Maria Manuel; Vieira, Ricardo; Alves, Rui; Figueiredo, AméricoIntroduction: Immunosuppression plays a central role in the pathogenesis of skin cancer in kidney transplant recipients. Recently, the potential for sirolimus to reduce the incidence of non-melanoma skin cancer in this population has been studied.Objective: To analyse the relationship between initial maintenance immunosuppressive regimens and the onset of non-melanoma skin cancer – squamous cell carcinoma and b...
Gemcitabine-Induced Bullous Acral Erythema
Pinto-Gouveia, Miguel; Coutinho, Inês; Ramos, Leonor; Brites, Maria Manuel; Cardoso, José Carlos; Tellechea, Óscar; Figueiredo, AméricoChemotherapy-induced acral erythema is characterized by areas of painful erythema affecting predominantly hands and feet, and in severe cases bullous lesions may develop. Gemcitabine is frequently responsible for cutaneous side effects, but these are usually mild and transient. We report a patient under palliative chemotherapy for pancreatic ductal adenocarcinoma with gemcitabine, who presented large bullous le...
SENTINEL NODE BIOPSY IN PORTUGAL - THE EXPERIENCE OF A REFERENCE A CENTER
Teixeira, Vera; Vieira, Ricardo; Coutinho, Inês; Cabral, Rita; Andrade, Pedro; Julião, Maria José; Brites, Maria Manuel; Albuquerque, AnabelaBackground: Sentinel lymph node biopsy is undertaken as a standard procedure for patients with localized cutaneous melanoma. The National Comprehensive Cancer Network (NCCN) melanoma panel has reinforced the status of Sentinel lymph node biopsy as the most important prognostic factor for disease survival.Objectives: We sought to identify predictive factors associated with positive SLN biopsy and correlation wit...
SQUAMOUS CELL CARCINOMA OF THE SCROTUM
Teixeira, Vera; Coutinho, Inês; Brites, Maria Manuel; Vieira, Ricardo; Tellechea, Óscar; Figueiredo, AméricoIntroduction: Squamous cell carcinoma of the scrotum is a rare tumour. It was the first cancer directly linked to occupational exposure to carcinogens (polycyclic aromatic hydrocarbons).Clinical Case: A 59-year old man was referred with a one year history of a painful scrotal ulcer, 8 cm in diameter, associated with genital lymphedema. Histological examination confirmed the diagnosis of squamous cell carcinoma....
Synchronous pyoderma gangrenosum and inflammatory bowel disease, healing after ...
Andrade, Pedro; Brites, Maria Manuel; Figueiredo, AméricoWe present a female patient observed with painful violaceous plaques with central bullae and pustules on the lower limbs, rapidly transformed into ulcers, associated with bloody diarrhea, recurrent oral erosions and hyperthermia in the previous 3 months. Cutaneous biopsy was consistent with pyoderma gangrenosum, and intestinal diagnostic procedures revealed a non-classifiable inflammatory bowel disease with hig...