49 documents found, page 1 of 5
Comparison of functioning and health-related quality of life among patients wit...
Marconi,Cleyde Sheyla Chachaqui; Lins-Kusterer,Liliane; Brites,Carlos; Gomes-Neto,MansuetoAbstract INTRODUCTION: Human immunodeficiency virus (HIV) and human T-cell leukemia virus-1 (HTLV-1) viruses are associated with a high global burden of disease, and coinfection is a frequently reported event. We aimed to compare the functioning and health-related quality of life (HRQoL) of patients infected with HTLV-1, HIV, and HIV-HTLV-1. METHODS: We conducted a cross-sectional study of patients older than 1...
Brazilian Protocol for Sexually Transmitted Infections 2020: human T-cell lymph...
Rosadas,Carolina; Brites,Carlos; Arakaki-Sanchez,Denise; Casseb,Jorge; Ishak,RicardoAbstract This article addresses the Human T-lymphotropic virus (HTLV). This subject comprises the Clinical Protocol and Therapeutic Guidelines for Comprehensive Care for People with Sexually Transmitted Infections, published by the Brazilian Ministry of Health. HTLV-1/2 infection is a public health problem globally, and Brazil has the largest number of individuals living with the virus. HTLV-1 causes several cl...
Pathogenesis of HTLV-1 infection and progression biomarkers: An overview
Brites,Carlos; Grassi,Maria Fernanda; Quaresma,Juarez Antônio Simões; Ishak,Ricardo; Vallinoto,Antonio Carlos RosárioABSTRACT Infection by human T-cell lymphotropic virus type 1 (HTLV-1) occurs in lymphocytes, which travel throughout the body, thus affecting several target organs and causing varied clinical outcomes, particularly in populations that are underserved and do not have access to healthcare. However, the mechanism of pathogenesis is not yet fully understood. The TAX and HTLV-1 basic leucine zipper factor (HBZ) prot...
Anxiety, health-related quality of life, and symptoms of burnout in frontline p...
Chalhub,Ricardo Ávila; Menezes,Marta Silva; Aguiar,Carolina Villa Nova; Santos-Lins,Larissa Souza; Martins Netto,Eduardo; Brites,CarlosABSTRACT Background: COVID-19 pandemic caused increased workload and stress for health professionals involved in the care of such patients. We aimed to describe the health-related quality of life, and burnout in frontline physicians diagnosed with anxiety during the COVID-19 pandemic. Methods: This was a cross-sectional study conducted during the first-wave phase of COVID19, from September to October 2020. Ques...
Seroprevalence and factors associated with Human Immunodeficiency virus, Human ...
Vargas,Ludy; Bastos,Fernanda; Guimarães,André; Amaral,Sávio; Fausto,Tarcisio; Arriaga,Maria; Sarno,Manoel; Brites,CarlosAbstract Background The heterogeneity in detection rates of Human immunodeficiency virus, (HIV), Human T lymphotropic virus (HTLV) and Hepatitis B and C infections among pregnant women and the continuous exposure to risk factors limits the adoption of preventive and control actions. Objective To evaluate the HIV, HTLV, Hepatitis B and C seroprevalence rates, and associated risk factors in parturient women in Sa...
Saliva is a reliable, non-invasive specimen for SARS-CoV-2 detection
Vaz,Sara Nunes; Santana,Daniele Souza de; Netto,Eduardo Martins; Pedroso,Celia; Wang,Wei-Kung; Santos,Felice Deminco Alves; Brites,CarlosAbstract Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease 2019 (COVID-19). Although Real Time Reverse Transcription Polymerase Chain Reaction (qRT-PCR) of respiratory specimens is the gold standard test for detection of SARS-CoV-2 infection, collecting nasopharyngeal swabs causes discomfort to patients and may represent considerable risk for healthcare ...
Immune response in SARS-CoV-2 infection: the role of interferons type I and typ...
Sousa,Caciane Portela; Brites,CarlosAbstract Background There is scarce information on the human immune response to the SARS-CoV-2 infection, and on the exacerbated inflammatory reaction observed in severe COVID-19 cases. Objective To review the available evidence on the role of interferons type I and type III to SARS-CoV-2 infection. Methods We reviewed the available published evidence on the role of immune response to SARS-CoV-2 infection as we...
A SYSTEMATIC REVIEW ON THE INFLUENCE OF HLA-B POLYMORPHISMS ON HIV-1 MOTHER-TO-...
Angulo,Juan Manuel Cubillos; Cuesta,Taryn Ariadna Castro; Menezes,Eliane Pereira; Pedroso,Celia; Brites,CarlosABSTRACT Background: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection. Objective: To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT. Methods: Two independent reviewers performed a systematic review on search engines PubMed, Europe ...
HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil
Angulo,Juan Manuel Cubillos; Cuesta,Taryn Ariadna Castro; Menezes,Eliane Pereira; Pedroso,Celia; Brites,CarlosABSTRACT Background: Class I human leukocyte antigens, especially the molecules encoded at the B locus (HLA-B), are associated with AIDS progression risk. Different groups of HLA-B alleles have been associated to a protective effect or increasing susceptibility to HIV infection and are expressed from the earliest stages of gestation. Objective: The aim of this study was to evaluate which variants of HLA-B are a...
Factors associated with mortality in HIV patients failing antiretroviral therap...
Haguihara,Tatiana; Silva,Márcio da Oliveira; Rebouças,Monaliza Cardozo; Martins Netto,Eduardo; Brites,CarlosABSTRACT Highly active antiretroviral therapy (HAART) has significantly improved survival of people living with HIV/Aids (PLWHA). However, poor treatment adherence to HAART and other problems, still cause therapy failure and contribute to increased morbidity and mortality of PLWHA. In this retrospective cohort study (2013-2015), we sought to evaluate the factors associated with mortality of PLWHA failing HAART ...