4 documents found, page 1 of 1
BRD9 status is a major contributor for cysteine metabolic remodeling through MS...
Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; Oliva, Abel; C. Barral, DuartePublisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.; Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing incidence. Hereditary CM accounts for a significant percentage (5-15 %) of all CM cases. However, most familial cases remain without a known genetic cause. Even though, BRD9 has been associated to CM as a susceptibility gene. ...
Unraveling the relevance of arl gtpases in cutaneous melanoma prognosis through...
Brito, Cheila; Costa‐silva, Bruno; C. Barral, Duarte; Pojo, MartaFunding Information: Funding: This research was funded by iNOVA4Health—UIDB/04462/2020, a program financially supported by the Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência. M.P. was funded by the Liga Portuguesa Contra o Cancro ‒ Núcleo Regional do Sul (LPCC‐NRS). D.B. was funded by the FCT Investigator Program (IF/00501/2014/CP1252/CT0001). Publisher Copyright: © 2021 by the authors. L...
High-throughput sequencing identifies 3 novel susceptibility genes for heredita...
Campos, Catarina; Fragoso, Sofia; Luís, Rafael; Pinto, Filipe; Brito, Cheila; Esteves, Susana; Pataco, Margarida; Santos, Sidónia; Machado, PatríciaFunding: The authors are thankful for the collaboration of all departments involved from IPOLFG, Lisboa, Portugal. F.P. received a grant from National Funds through the Foundation for Science and Technology (FCT), reference SFRH/BPD/115730/2016. The authors are thankful for the financial support to Liga Portuguesa Contra o Cancro, Núcleo Regional Sul (LPCC-NRS), IPOLFG, TVI (Televisão Independente) and iNOVA4He...
Subversion of Ras Small GTPases in Cutaneous Melanoma Aggressiveness
Brito, Cheila; C. Barral, Duarte; Pojo, MartaThe rising incidence and mortality rate associated with the metastatic ability of cutaneous melanoma represent a major public health concern. Cutaneous melanoma is one of the most invasive human cancers, but the molecular mechanisms are poorly understood. Moreover, currently available therapies are not efficient in avoiding melanoma lethality. In this context, new biomarkers of prognosis, metastasis, and respon...