23 documents found, page 1 of 3
Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3’A host genetic factors in HI...
Sebastião, Cruz S.; Pimentel, Victor; Jandondo, Domingos; Sebastião, Joana M. K.; Sacomboio, Euclides N. M.; Pingarilho, Marta; Brito, MiguelFunding Information: This research was funded by the Fundação Calouste Gulbenkian (FCG), under the ENVOLVE Ciência PALOP program that funded the HITOLA project (Number 250466), FCT MARVEL (PTDC/SAU-PUB/4018/2021), FCT GHTM-UID/04413/2020 and LA-REAL-LA/P/0117/2020. Publisher Copyright: © The Author(s) 2025.; Background: The HIV/AIDS pandemic remains a public health concern. Studies on host genetic polymorphisms...
Rotavirus alphagastroenteritidis
Vita, Dikudila G.; Santiso-Bellón, Cristina; Lemos, Manuel; Neto, Zoraima; Fortes-Gabriel, Elsa; Brito, Miguel; Sebastião, Cruz S.Funding Information: This research was funded by Abbott Rapid Diagnostics Group, the National Health Research Institute (INIS), Luanda, Angola, the Centro de Investigac & atilde;o em Saude de Angola (CISA), Angola, and the Gulbenkian Foundation, Lisbon, Portugal. The study sponsors had no role in the design of this study. Publisher Copyright: © 2025 by the authors.; Rotavirus alphagastroenteritidis (R. alphagas...
Magnetic and levitation properties of YBCO/polymer composite drop-casting films
Lucas, Beatriz; Brito, Miguel; Aksoy, Canan; Cakir, Bakiye; Coşkun, Elvan; Gencer, Ali; Pronto, Anabela; Ferreira, IsabelThis work was also supported by ERC-CoG-2014 , CapTherPV , 647596 . Publisher Copyright: © 2025 The Authors; Superconducting materials have been extensively studied for various applications, with YBCO alloys among the most researched and widely applied. This paper investigates the feasibility of using YBCO powder-based inks to produce cost-effective films with magnetic properties. Our studies demonstrate that l...
DNA Methyltransferase Expression (DNMT1, DNMT3a, and DNMT3b) as a Potential Bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Caldeira Rosa, Paulo; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoPublisher Copyright: © 2025 by the authors.; Background/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. M...
Characterization of a cohort of Angolan children with sickle cell anemia treate...
dos Santos, Brígida; Ginete, Catarina; Gonçalves, Elisângela; Delgadinho, Mariana; Miranda, Armandina; Faustino, Paula; Arez, Ana Paula; Brito, MiguelThis research was funded by Fundacao para a Ciencia e Tecnologia Ministerio da Ciencia, Tecnologia e Ensino Superior (FCT-MCTES) and Aga Khan Foundation (FCT/MCTES/Aga Khan, project no 330842553), by FCT/MCTES funding to H&TRC (UIDB/05608/2020, UIDP/05608/2020) and to GHTM IHMT NOVA (UID/04413/2020) and LA-REAL - LA/P/0117/2020.; Background Sickle Cell Anemia (SCA) is a monogenic disease, although its severity ...
Using Portuguese BRCA pathogenic variation as a model to study the impact of hu...
Andaluz, Stephanie; Zhao, Bojin; Sinha, Siddharth; Lagniton, Philip Naderev Panuringan; Costa, Diogo Alpuim; Ding, Xiaofan; Brito, MiguelBackground: Admixture occurs between different ethnic human populations. The global colonization in recent centuries by Europeans led to the most significant admixture in human history. While admixture may enhance genetic diversity for better fitness, it may also impact on human health by transmitting genetic variants for disease susceptibility in the admixture population. The admixture by Portuguese global exp...
Sickle Cell Disease and Gut Health
Delgadinho, Mariana; Ginete, Catarina; Santos, Brígida; de Vasconcelos, Jocelyne Neto; Arez, Ana Paula; Brito, MiguelFunding Information: This work was funded by the following grants: IPL/IDI&CA2022/ParasitSCD, FCT/Aga Khan (project no. 330842553), and FCT/MCTES (https://doi.org/10.54499/UIDB/05608/2020 and https://doi.org/10.54499/UIDP/05608/2020)-H&TRC. Author M.D. has received financial support from an FCT research fellowship UI/BD/150705/2020 (https://doi.org/10.54499/UI/BD/150705/2020). Publisher Copyright: © 2024 by the...
Sickle Cell Disease
Gonçalves, Elisângela; Smaoui, Slim; Brito, Miguel; Oliveira, J M; Arez, Ana Paula; Tavares, LolenyFunding Information: Miguel Brito gratefully acknowledges the FCT/MCTES national support through the projects H&TRC UIDB/05608/2020, UIDP/05608/2020, and IPL/IDI&CA2023/Ipasthma_ESTeSL. J.M. Oliveira acknowledges the financial support of CICECO\u2013Aveiro Institute of Materials, UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020), UIDP/50011/2020 (DOI 10.54499/UIDP/50011/2020) & LA/P/0006/2020 (DOI 10.54499/LA/P/00...
HIV-1 diversity and pre-treatment drug resistance in the era of integrase inhib...
Sebastião, Cruz S.; Abecasis, Ana B.; Jandondo, Domingos; Sebastião, Joana M. K.; Vigário, João; Comandante, Felícia; Pingarilho, MartaFunding Information: We would like to thank all subjects who participated in this study and all staff of the National Blood Institute (Mr Alberto Sozinho, Ms Eunice Manico, and Ms Deodete Machado) and the research team of CISA/INIS for the data collection (Mr Pedro Vienga and Mr Agostinho Tchipeta) for the data collection, the laboratory technician (Ms. Anabela Mateus), and administrative staff members (Zinga D...
Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Su...
Cidade do Carmo, Catarina; Brito, Miguel; Oliveira, J. P.; Marques, Ana; Ferreira, Isabel; Baptista, Ana CatarinaPublisher Copyright: © 2024 by the authors.; This study explores a method that has the potential to be cost effective in inhibiting biofilm formation on metallic prostheses, thereby preventing rejection or the requirement for replacement. A cost-effective metal alloy used in biomedical implants was chosen as the substrate, and ibuprofen (Ibu), a well-known anti-inflammatory drug, was selected for drug release t...