9 documents found, page 1 of 1

Precise multiphase hydrogel engineering of miniaturized 3D cancer architectures...

Understanding cancer biology and therapy responses requires accurate in vitro models that reflect tumor complexity. This work presents a multiphase microfluidic biofabrication approach for creating self-standing three-dimensional (3D) tumor models within hydrogel microfiber boundaries. A single framework enabled the fast generation of different in vitro cellular configurations, including discrete spheroids ...

Cooling rate uncovers epimer-dependent supramolecular organization of carbohydr...

We show distinct CH-pi interactions and assembly pathways for the amphiphile N-(fluorenylmethoxycarbonyl)-galactosamine and its epimer N-(fluorenylmethoxycarbonyl)-glucosamine. These differences result in the formation of supramolecular nanofibrous systems with opposite chirality. Our results showcase the importance of the carbohydrates structural diversity for their specific biointeractions and the opportunity...

Multifunctional calcium-based nanocarriers for synergistic treatment of triple-...

Targeted breast cancer therapies hold the potential to improve the efficiency of drug delivery to the pathology site without impacting the viability and function of healthy cells. Herein, we developed multifunctional nanocarriers that target simultaneously several downstream signaling processes in triple negative breast cancer cells. The system comprises pH sensitive CaCO3 nanoparticles (NPs) as carriers of the...

Efficacy of molecular and nano-therapies on brain tumor models in microfluidic ...

The three-dimensional (3D) organization of cells affects their mobility, proliferation, and overall response to treatment. Spheroids, organoids, and microfluidic chips are used in cancer research to reproduce in vitro the complex and dynamic malignant microenvironment. Herein, single-and double-channel microfluidic devices are used to mimic the spatial organization of brain tumors and investigate the therapeuti...

Detection of drug resistant Mycobacterium Tuberculosis strains using kit SIRE N...

This research was funded by MINAS GERAIS STATE RESEARCH SUPPORT FOUNDATION (FAPEMIG), grants numbers 65/10 and CDS-APQ-03266-13, and by NATIONAL COUNCIL FOR SCIENTIFIC AND TECHNOLOGICAL DEVELOPMENT (CNPQ) grants numbers 310174/2014-7 and 446796/2014-0.; Federal University of Minas Gerais. Faculty of Medicine. Mycobacteria Research Laboratory. Belo Horizonte, MG, Brazil.; Federal University of Minas Gerais. Facu...

Inhibiting cancer metabolism by aromatic carbohydrate amphiphiles that act as a...

We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the cell surface through localized (biocatalytic) self-assembly. We demonstrate that the expression of the cancer asso...

Articulação entre a gestão da água e a conservação da natureza e da biodiversidade

Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestas...

Objective(s): The present work was conducted to clarify the relevance of usual liver function tests, and define the most predictive serum bile acid profile for diagnosis of intrahepatic cholestasis of pregnancy (ICP). Study design: This study comprised 20 healthy nonpregnant women and 77 pregnant women in the last trimester of pregnancy, from which 38 were normal pregnancies, and 39 suffered from ICP. Liver fun...

Effect of bilirubin on erythrocyte shape and haemolysis, under hypotonic, aggre...