3 documents found, page 1 of 1
Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumo...
Laranjo, Mafalda; Aguiar, Márcia Campos; Pereira, Nelson A. M.; Brites, Gonçalo; Nascimento, Bruno F. O.; Brito, Ana F.; Casalta-Lopes, JoãoThe discovery of Pt-chlorin-type theranostic agents is described. Luminescent Pt(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, with different degrees of hydrophilicity, have been synthesized and their in vitro photocytotoxicity against human melanoma, oesophageal and bladder carcinomas was studied. A di(hydroxymethyl)-substituted chlorin was identified as a privileged molecule to explore imaging...
Doping β-TCP as a Strategy for Enhancing the Regenerative Potential of Composit...
Ferreira, Manuel M.; Brito, Ana F.; Brazete, Daniela; Pereira, Inês C.; Carrilho, Eunice; Abrantes, Ana M.; Pires, Ana S.; Aguiar, Maria JThe present work aims at evaluating the potential gains derived from partially replacing calcium in resorbable β-tricalcium phosphate (β-TCP) by two different molar percentages of strontium (5, 10) and zinc (1, 2), concomitantly with a fixed molar percentage (0.5) of manganese. Synthetic granular composite bone filling grafts consisting of doped β-TCP and an alkali-free bioactive glass were prepared and implant...
Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H...
Santos, Kathleen; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana F.; Gonçalves, Cristina; Ribeiro, Ana Bela Sarmento; Botelho, M. FilomenaFurther studies on 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against breast cancer are reported, allowing to demonstrate the potential of these compounds for the therapy of the triple-negative breast cancer, the most challenging tumors in clinical practice. These compounds were assayed for their in vitro cytotoxicity on several human breast cancer cell lines (MCF7, HCC1954 and HC...